Enterotoxigenic Escherichia coli heat labile enterotoxin inhibits intestinal ascorbic acid uptake via a cAMP-dependent NF-κB-mediated pathway

Vitamin C is an antioxidant and acts as a cofactor for many enzymatic reactions. Humans obtain vitamin C from dietary sources via intestinal absorption, a process that involves the sodium-dependent vitamin C transporters-1 and -2 (SVCT1 and SVCT2). Enterotoxigenic Escherichia coli (ETEC) infection i...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2019-01, Vol.316 (1), p.G55-G63
Hauptverfasser:	Subramenium, Ganapathy A, Sabui, Subrata, Marchant, Jonathan S, Said, Hamid M, Subramanian, Veedamali S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adenylate cyclase Animals Antioxidants Ascorbic acid Ascorbic Acid - pharmacology Biological Transport - drug effects Caco-2 Cells Cyclic AMP E coli Effects Enterotoxigenic Escherichia coli - chemistry Enterotoxins - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Escherichia coli Escherichia coli Infections - metabolism Gene expression hnRNA Humans Intestinal absorption Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Intestines - drug effects NF-kappa B - metabolism NF-κB protein Proteins Sodium Sodium-Coupled Vitamin C Transporters - drug effects Sodium-Coupled Vitamin C Transporters - metabolism Transcription Vitamins - metabolism
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