Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug

Abstract Aims Nitroglycerine (NTG) given prior to an ischaemic insult exerts cardioprotective effects. However, whether administration of an acute low dose of NTG in a clinically relevant manner following an ischaemic episode limits infarct size, has not yet been explored. Methods and results Adult...

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Veröffentlicht in:	Cardiovascular research 2019-03, Vol.115 (3), p.625-636
Hauptverfasser:	Bibli, Sofia-Iris, Papapetropoulos, Andreas, Iliodromitis, Efstathios K, Daiber, Andreas, Randriamboavonjy, Voahanginirina, Steven, Sebastian, Brouckaert, Peter, Chatzianastasiou, Athanasia, Kypreos, Kyriakos E, Hausenloy, Derek J, Fleming, Ingrid, Andreadou, Ioanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Cyclophilins - antagonists & inhibitors Cyclophilins - genetics Cyclophilins - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Female Humans Male Mice, Inbred C57BL Mice, Knockout, ApoE Middle Aged Myocardial Infarction - enzymology Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - pathology Necrosis Nitric Oxide Donors - pharmacology Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nitroglycerin - pharmacology Nitrosation Original Signal Transduction
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