A Dynamic Hydrophobic Core and Surface Salt Bridges Thermostabilize a Designed Three-Helix Bundle

Thermostable proteins are advantageous in industrial applications, as pharmaceuticals or biosensors, and as templates for directed evolution. As protein-design methodologies improve, bioengineers are able to design proteins to perform a desired function. Although many rationally designed proteins en...

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Veröffentlicht in:	Biophysical journal 2019-02, Vol.116 (4), p.621-632
Hauptverfasser:	Nguyen, Catrina, Young, Jennifer T., Slade, Gabriel G., Oliveira, Ronaldo J., McCully, Michelle E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Entropy Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Molecular Dynamics Simulation Monte Carlo Method Movement Protein Conformation, alpha-Helical Protein Stability Proteins - chemistry Proteins - metabolism Static Electricity Temperature
Online-Zugang:	Volltext
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