Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual

Osteoblasts, which are the bone-forming cells, operate in a hypoxic environment. The transcription factors hypoxia-inducible factor-1α (HIF1) and HIF2 are key mediators of the cellular response to hypoxia. Both are expressed in osteoblasts. HIF1 is known to be a positive regulator of bone formation....

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Veröffentlicht in:	Bone Research 2019-02, Vol.7 (1), p.7-7, Article 7
Hauptverfasser:	Merceron, Christophe, Ranganathan, Kavitha, Wang, Elizabeth, Tata, Zachary, Makkapati, Shreya, Khan, Mohd Parvez, Mangiavini, Laura, Yao, Angela Qing, Castellini, Laura, Levi, Benjamin, Giaccia, Amato J., Schipani, Ernestina
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319/1557 631/443/63 Hypoxia Internal Medicine Medicine Medicine & Public Health Orthopedics
Online-Zugang:	Volltext
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