Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma
To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in preperimetric and early primary open-angle glaucoma (POAG) eyes. Cross-sectional study. Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma...
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| Veröffentlicht in: | American journal of ophthalmology 2019-03, Vol.199, p.120-132 |
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| creator | Hou, Huiyuan Moghimi, Sasan Zangwill, Linda M. Shoji, Takuhei Ghahari, Elham Penteado, Rafaella C. Akagi, Tadamichi Manalastas, Patricia Isabel C. Weinreb, Robert N. |
| description | To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in preperimetric and early primary open-angle glaucoma (POAG) eyes.
Cross-sectional study.
Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A)-based superficial macula vessel density and OCT-based GCC thickness were evaluated simultaneously. Percent loss from normal of GCC thickness and macula vessel density was compared. Area under the receiver operating characteristic curve was used to describe the diagnostic utility.
Both GCC thickness and vessel density were significantly lower in preperimetric and early POAG eyes compared to healthy eyes. Compared to the preperimetric POAG group, the early POAG group showed larger GCC thickness percent loss (whole image 4.72% vs 9.86%; all P < .01) but similar vessel density percent loss (whole image 4.97% vs 6.93%; all P > .05). In preperimetric POAG, GCC thickness and vessel density percent losses were similar (all P > .1). In contrast, in early POAG, GCC thickness percent loss was larger than that of vessel density (all P ≤ .001). To discriminate preperimetric or early glaucoma eyes from healthy eyes, GCC thickness and macula vessel density showed similar diagnostic accuracy (all P > .05).
Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes. GCC loss was greater than macula vessel density loss in early perimetric POAG. However, OCT-A and OCT measurements showed similar efficiency to detect early glaucoma. |
| doi_str_mv | 10.1016/j.ajo.2018.11.012 |
| format | Article |
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Cross-sectional study.
Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A)-based superficial macula vessel density and OCT-based GCC thickness were evaluated simultaneously. Percent loss from normal of GCC thickness and macula vessel density was compared. Area under the receiver operating characteristic curve was used to describe the diagnostic utility.
Both GCC thickness and vessel density were significantly lower in preperimetric and early POAG eyes compared to healthy eyes. Compared to the preperimetric POAG group, the early POAG group showed larger GCC thickness percent loss (whole image 4.72% vs 9.86%; all P < .01) but similar vessel density percent loss (whole image 4.97% vs 6.93%; all P > .05). In preperimetric POAG, GCC thickness and vessel density percent losses were similar (all P > .1). In contrast, in early POAG, GCC thickness percent loss was larger than that of vessel density (all P ≤ .001). To discriminate preperimetric or early glaucoma eyes from healthy eyes, GCC thickness and macula vessel density showed similar diagnostic accuracy (all P > .05).
Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes. GCC loss was greater than macula vessel density loss in early perimetric POAG. However, OCT-A and OCT measurements showed similar efficiency to detect early glaucoma.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2018.11.012</identifier><identifier>PMID: 30496723</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Cross-Sectional Studies ; Early Diagnosis ; Female ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Gonioscopy ; Humans ; Intraocular Pressure - physiology ; Macula Lutea - blood supply ; Male ; Middle Aged ; Nerve Fibers - pathology ; Retinal Diseases - diagnosis ; Retinal Ganglion Cells - pathology ; Retinal Vessels - pathology ; Tomography, Optical Coherence - methods ; Tonometry, Ocular ; Visual Field Tests ; Visual Fields - physiology</subject><ispartof>American journal of ophthalmology, 2019-03, Vol.199, p.120-132</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-d28ee218a934c035a180b5056818ddb87f604e02f043e6355d93d7297523cb463</citedby><cites>FETCH-LOGICAL-c451t-d28ee218a934c035a180b5056818ddb87f604e02f043e6355d93d7297523cb463</cites><orcidid>0000-0003-1461-8808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000293941830655X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30496723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hou, Huiyuan</creatorcontrib><creatorcontrib>Moghimi, Sasan</creatorcontrib><creatorcontrib>Zangwill, Linda M.</creatorcontrib><creatorcontrib>Shoji, Takuhei</creatorcontrib><creatorcontrib>Ghahari, Elham</creatorcontrib><creatorcontrib>Penteado, Rafaella C.</creatorcontrib><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Manalastas, Patricia Isabel C.</creatorcontrib><creatorcontrib>Weinreb, Robert N.</creatorcontrib><title>Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in preperimetric and early primary open-angle glaucoma (POAG) eyes.
Cross-sectional study.
Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A)-based superficial macula vessel density and OCT-based GCC thickness were evaluated simultaneously. Percent loss from normal of GCC thickness and macula vessel density was compared. Area under the receiver operating characteristic curve was used to describe the diagnostic utility.
Both GCC thickness and vessel density were significantly lower in preperimetric and early POAG eyes compared to healthy eyes. Compared to the preperimetric POAG group, the early POAG group showed larger GCC thickness percent loss (whole image 4.72% vs 9.86%; all P < .01) but similar vessel density percent loss (whole image 4.97% vs 6.93%; all P > .05). In preperimetric POAG, GCC thickness and vessel density percent losses were similar (all P > .1). In contrast, in early POAG, GCC thickness percent loss was larger than that of vessel density (all P ≤ .001). To discriminate preperimetric or early glaucoma eyes from healthy eyes, GCC thickness and macula vessel density showed similar diagnostic accuracy (all P > .05).
Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes. GCC loss was greater than macula vessel density loss in early perimetric POAG. However, OCT-A and OCT measurements showed similar efficiency to detect early glaucoma.</description><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Gonioscopy</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Macula Lutea - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nerve Fibers - pathology</subject><subject>Retinal Diseases - diagnosis</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Retinal Vessels - pathology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Tonometry, Ocular</subject><subject>Visual Field Tests</subject><subject>Visual Fields - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1DAQtRCoXUo_gAvykUuCx3YcR0hIVVtapKJyKFwtrz3bevE6i51U2r_H1ZaKXnoazcybN0_vEfIeWAsM1Kd1a9djyxnoFqBlwF-RBeh-aEAP8JosGGO8GcQgD8nbUta1Vb3sD8ihYHJQPRcLcvndujla-gtLwUjPMJUw7ahNnt7cBfc71TkNiZ7bHHf0Rw4bm3f0eoupOUm3EelFtLMbN_YdebOyseDxYz0iP7-e35xeNlfXF99OT64aJzuYGs81IgdtByEdE50FzZYd65QG7f1S9yvFJDK-YlKgEl3nB-F7PvQdF24plTgiX_a823m5Qe8wTdlGs90rM6MN5vkmhTtzO94bJTRXICvBx0eCPP6ZsUxmE4rDGG3CcS6GgwQmtRKsQmEPdXksJePq6Q0w85CAWZuagHlIwACYmkC9-fC_vqeLf5ZXwOc9AKtL9wGzKS5gcuhDRjcZP4YX6P8CJWqVqA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Hou, Huiyuan</creator><creator>Moghimi, Sasan</creator><creator>Zangwill, Linda M.</creator><creator>Shoji, Takuhei</creator><creator>Ghahari, Elham</creator><creator>Penteado, Rafaella C.</creator><creator>Akagi, Tadamichi</creator><creator>Manalastas, Patricia Isabel C.</creator><creator>Weinreb, Robert N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1461-8808</orcidid></search><sort><creationdate>20190301</creationdate><title>Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma</title><author>Hou, Huiyuan ; Moghimi, Sasan ; Zangwill, Linda M. ; Shoji, Takuhei ; Ghahari, Elham ; Penteado, Rafaella C. ; Akagi, Tadamichi ; Manalastas, Patricia Isabel C. ; Weinreb, Robert N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-d28ee218a934c035a180b5056818ddb87f604e02f043e6355d93d7297523cb463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Gonioscopy</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Macula Lutea - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nerve Fibers - pathology</topic><topic>Retinal Diseases - diagnosis</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Retinal Vessels - pathology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Tonometry, Ocular</topic><topic>Visual Field Tests</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Huiyuan</creatorcontrib><creatorcontrib>Moghimi, Sasan</creatorcontrib><creatorcontrib>Zangwill, Linda M.</creatorcontrib><creatorcontrib>Shoji, Takuhei</creatorcontrib><creatorcontrib>Ghahari, Elham</creatorcontrib><creatorcontrib>Penteado, Rafaella C.</creatorcontrib><creatorcontrib>Akagi, Tadamichi</creatorcontrib><creatorcontrib>Manalastas, Patricia Isabel C.</creatorcontrib><creatorcontrib>Weinreb, Robert N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Huiyuan</au><au>Moghimi, Sasan</au><au>Zangwill, Linda M.</au><au>Shoji, Takuhei</au><au>Ghahari, Elham</au><au>Penteado, Rafaella C.</au><au>Akagi, Tadamichi</au><au>Manalastas, Patricia Isabel C.</au><au>Weinreb, Robert N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>199</volume><spage>120</spage><epage>132</epage><pages>120-132</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in preperimetric and early primary open-angle glaucoma (POAG) eyes.
Cross-sectional study.
Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A)-based superficial macula vessel density and OCT-based GCC thickness were evaluated simultaneously. Percent loss from normal of GCC thickness and macula vessel density was compared. Area under the receiver operating characteristic curve was used to describe the diagnostic utility.
Both GCC thickness and vessel density were significantly lower in preperimetric and early POAG eyes compared to healthy eyes. Compared to the preperimetric POAG group, the early POAG group showed larger GCC thickness percent loss (whole image 4.72% vs 9.86%; all P < .01) but similar vessel density percent loss (whole image 4.97% vs 6.93%; all P > .05). In preperimetric POAG, GCC thickness and vessel density percent losses were similar (all P > .1). In contrast, in early POAG, GCC thickness percent loss was larger than that of vessel density (all P ≤ .001). To discriminate preperimetric or early glaucoma eyes from healthy eyes, GCC thickness and macula vessel density showed similar diagnostic accuracy (all P > .05).
Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes. GCC loss was greater than macula vessel density loss in early perimetric POAG. However, OCT-A and OCT measurements showed similar efficiency to detect early glaucoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30496723</pmid><doi>10.1016/j.ajo.2018.11.012</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-1461-8808</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Cross-Sectional Studies Early Diagnosis Female Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Gonioscopy Humans Intraocular Pressure - physiology Macula Lutea - blood supply Male Middle Aged Nerve Fibers - pathology Retinal Diseases - diagnosis Retinal Ganglion Cells - pathology Retinal Vessels - pathology Tomography, Optical Coherence - methods Tonometry, Ocular Visual Field Tests Visual Fields - physiology |
| title | Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma |
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