The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease

Herpes simplex virus (HSV)− 1 is the most common cause of sporadic viral encephalitis and accounts for 5–10% of cases worldwide. A key factor in host control of viral infection is the initiation of the interferon (IFN) response, mediated in part by the stimulator of interferon genes (STING) pathway....

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2019-03, Vol.529, p.23-28
Hauptverfasser:	Cerón, Stacey, North, Brian J., Taylor, Sean A., Leib, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Central Nervous System Viral Diseases - prevention & control DMXAA Female Fibroblasts - virology Gene Expression Regulation - drug effects Herpes Simplex Herpes simplex virus Immunotherapy antiviral therapy Interferon-beta - genetics Interferon-beta - metabolism Male Membrane Proteins - agonists Mice Mice, Inbred C57BL Simplexvirus STING Virus Replication - drug effects Xanthones - therapeutic use
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