Cardiolipin Alters Rhodobacter sphaeroides Cell Shape by Affecting Peptidoglycan Precursor Biosynthesis

Cardiolipin (CL) is an anionic phospholipid that plays an important role in regulating protein biochemistry in bacteria and mitochondria. Deleting the CL synthase gene (Δ ) in depletes CL and decreases cell length by 20%. Using a chemical biology approach, we found that a CL deficiency does not impa...

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Veröffentlicht in:	mBio 2019-02, Vol.10 (1)
Hauptverfasser:	Lin, Ti-Yu, Gross, William S, Auer, George K, Weibel, Douglas B
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Outer Membrane Proteins - metabolism Biosynthetic Pathways Cardiolipins - metabolism Cell Wall - metabolism Gene Deletion Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Biology and Physiology N-Acetylglucosaminyltransferases - metabolism Rhodobacter sphaeroides - cytology Rhodobacter sphaeroides - metabolism Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives Uridine Diphosphate N-Acetylmuramic Acid - biosynthesis
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