Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer

Oxaliplatin is important for the clinical treatment of colorectal cancer and other gastrointestinal malignancies, but tumour resistance is limiting. Several oxaliplatin transporters were previously identified but their relative contributions to determining oxaliplatin tumour responses and gastrointe...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2245-2245, Article 2245
Hauptverfasser:	Myint, Khine, Biswas, Riya, Li, Yan, Jong, Nancy, Jamieson, Stephen, Liu, Johnson, Han, Catherine, Squire, Christopher, Merien, Fabrice, Lu, Jun, Nakanishi, Takeo, Tamai, Ikumi, McKeage, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 45/61 64/60 692/4028/67/1059 692/4028/67/1504 Accumulation Animal models Cancer screening Chemotherapy Colorectal cancer Colorectal carcinoma Cytotoxicity Humanities and Social Sciences multidisciplinary Overexpression Oxaliplatin Patients Science Science (multidisciplinary) siRNA Transfection Tumors Xenografts
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