A negative feedback loop between XBP1 and Fbw7 regulates cancer development

In cancer, activation of X-box binding protein (XBP1) has a critical role in tumorigenesis and cancer progression. Transcriptional regulatory mechanism of XBP1 in cancer development has been well known, however, regulation of ubiquitination and degradation of XBP1 has not been elucidated yet. Here w...

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Veröffentlicht in:	Oncogenesis (New York, NY) NY), 2019-02, Vol.8 (3), p.12-12, Article 12
Hauptverfasser:	Chae, Unbin, Lee, Heejin, Kim, Bokyung, Jung, Haiyoung, Kim, Byeong Mo, Lee, Ann- Hwee, Lee, Dong-Seok, Min, Sang-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/109 14/63 38/1 38/22 38/70 38/77 38/90 42/44 631/67/2327 631/80/86/2366 Activator protein 1 Apoptosis Cancer Cell Biology Cullin E2F1 protein Feedback Human Genetics Internal Medicine Medicine Medicine & Public Health Myc protein NF-κB protein Oncology Phosphorylation Signal transduction Transcription factors Tumorigenesis Ubiquitin-protein ligase Ubiquitination
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