Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort
Abstract Background In Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents. Methods Da...
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| Veröffentlicht in: | International journal of epidemiology 2019-02, Vol.48 (1), p.148-156 |
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| creator | Lule, Swaib A Namara, Benigna Akurut, Helen Muhangi, Lawrence Lubyayi, Lawrence Nampijja, Margaret Akello, Florence Tumusiime, Josephine Aujo, Judith C Oduru, Gloria Smeeth, Liam Elliott, Alison M Webb, Emily L |
| description | Abstract
Background
In Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents.
Methods
Data were collected prenatally from women and their offspring were followed from birth, with BP measured following standard protocols in early adolescence. Weight-for-age Z-scores (WAZ) were computed using World Health Organization references. Linear regression was used to relate BW, and changes in WAZ between birth and 5 years, to adolescents’ BP, adjusting for confounders.
Results
Among 2345 live offspring, BP was measured in 1119 (47.7%) adolescents, with mean systolic BP 105.9 mmHg and mean diastolic BP 65.2 mmHg. There was little evidence of association between BW and systolic [regression coefficient β = 0.14, 95% confidence interval (CI) (-1.00, 1.27)] or diastolic [β = 0.43, 95% CI (-0.57, 1.43)] BP. Accelerated weight gain between birth and 5 years was associated with increased BP: systolic β = 1.17, 95% CI (0.69, 1.66) and diastolic β = 1.03, 95% CI (0.59, 1.47). Between birth and 6 months of age, effects of accelerated weight gain on adolescent BP were strongest among the LBW (both premature and small-for-gestational-age) children [BW |
| doi_str_mv | 10.1093/ije/dyy118 |
| format | Article |
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Background
In Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents.
Methods
Data were collected prenatally from women and their offspring were followed from birth, with BP measured following standard protocols in early adolescence. Weight-for-age Z-scores (WAZ) were computed using World Health Organization references. Linear regression was used to relate BW, and changes in WAZ between birth and 5 years, to adolescents’ BP, adjusting for confounders.
Results
Among 2345 live offspring, BP was measured in 1119 (47.7%) adolescents, with mean systolic BP 105.9 mmHg and mean diastolic BP 65.2 mmHg. There was little evidence of association between BW and systolic [regression coefficient β = 0.14, 95% confidence interval (CI) (-1.00, 1.27)] or diastolic [β = 0.43, 95% CI (-0.57, 1.43)] BP. Accelerated weight gain between birth and 5 years was associated with increased BP: systolic β = 1.17, 95% CI (0.69, 1.66) and diastolic β = 1.03, 95% CI (0.59, 1.47). Between birth and 6 months of age, effects of accelerated weight gain on adolescent BP were strongest among the LBW (both premature and small-for-gestational-age) children [BW < 2.5 kg: β = 2.64, 95% CI (0.91, 4.37), BW≥2.5 kg: β = 0.58, 95% CI (0.01, 1.14), interaction P-value = 0.024].
Conclusions
Findings from this large tropical birth cohort in Uganda suggest that postnatal weight gain rather than BW is important in the developmental programming of BP, with fast-growing LBW children at particular risk. Efforts to control BP should adopt a life course approach.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyy118</identifier><identifier>PMID: 29982658</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adolescent ; Birth Weight ; Blood Pressure ; Child ; Child Development ; Child, Preschool ; Childhood Obesity and Weight Gain ; Cohort Studies ; Female ; Humans ; Hypertension - epidemiology ; Infant ; Infant, Low Birth Weight - growth & development ; Infant, Newborn ; Linear Models ; Male ; Randomized Controlled Trials as Topic ; Uganda - epidemiology ; Weight Gain</subject><ispartof>International journal of epidemiology, 2019-02, Vol.48 (1), p.148-156</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-6fce8ced69e4fe64f5fc467d4790968d5772ae0bfe044967604fce7bd44fa9883</citedby><cites>FETCH-LOGICAL-c408t-6fce8ced69e4fe64f5fc467d4790968d5772ae0bfe044967604fce7bd44fa9883</cites><orcidid>0000-0002-6271-2033</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29982658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lule, Swaib A</creatorcontrib><creatorcontrib>Namara, Benigna</creatorcontrib><creatorcontrib>Akurut, Helen</creatorcontrib><creatorcontrib>Muhangi, Lawrence</creatorcontrib><creatorcontrib>Lubyayi, Lawrence</creatorcontrib><creatorcontrib>Nampijja, Margaret</creatorcontrib><creatorcontrib>Akello, Florence</creatorcontrib><creatorcontrib>Tumusiime, Josephine</creatorcontrib><creatorcontrib>Aujo, Judith C</creatorcontrib><creatorcontrib>Oduru, Gloria</creatorcontrib><creatorcontrib>Smeeth, Liam</creatorcontrib><creatorcontrib>Elliott, Alison M</creatorcontrib><creatorcontrib>Webb, Emily L</creatorcontrib><title>Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort</title><title>International journal of epidemiology</title><addtitle>Int J Epidemiol</addtitle><description>Abstract
Background
In Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents.
Methods
Data were collected prenatally from women and their offspring were followed from birth, with BP measured following standard protocols in early adolescence. Weight-for-age Z-scores (WAZ) were computed using World Health Organization references. Linear regression was used to relate BW, and changes in WAZ between birth and 5 years, to adolescents’ BP, adjusting for confounders.
Results
Among 2345 live offspring, BP was measured in 1119 (47.7%) adolescents, with mean systolic BP 105.9 mmHg and mean diastolic BP 65.2 mmHg. There was little evidence of association between BW and systolic [regression coefficient β = 0.14, 95% confidence interval (CI) (-1.00, 1.27)] or diastolic [β = 0.43, 95% CI (-0.57, 1.43)] BP. Accelerated weight gain between birth and 5 years was associated with increased BP: systolic β = 1.17, 95% CI (0.69, 1.66) and diastolic β = 1.03, 95% CI (0.59, 1.47). Between birth and 6 months of age, effects of accelerated weight gain on adolescent BP were strongest among the LBW (both premature and small-for-gestational-age) children [BW < 2.5 kg: β = 2.64, 95% CI (0.91, 4.37), BW≥2.5 kg: β = 0.58, 95% CI (0.01, 1.14), interaction P-value = 0.024].
Conclusions
Findings from this large tropical birth cohort in Uganda suggest that postnatal weight gain rather than BW is important in the developmental programming of BP, with fast-growing LBW children at particular risk. Efforts to control BP should adopt a life course approach.</description><subject>Adolescent</subject><subject>Birth Weight</subject><subject>Blood Pressure</subject><subject>Child</subject><subject>Child Development</subject><subject>Child, Preschool</subject><subject>Childhood Obesity and Weight Gain</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - epidemiology</subject><subject>Infant</subject><subject>Infant, Low Birth Weight - growth & development</subject><subject>Infant, Newborn</subject><subject>Linear Models</subject><subject>Male</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Uganda - epidemiology</subject><subject>Weight Gain</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kVFrHCEUhaW0NJu0L_kBwZdCCUyjM67jvCSEkCaFQKE0z-LodcfgjlN1GvZX5C_XMNvQvBQE4fp5zj0chI4p-UJJ15y5Bzgzux2l4g1aUcZZ1XCxfotWpCGkWrctPUCHKT0QQhlj3Xt0UHedqPlarNDTZQTcu5iHR3CbIWM1GjyFlEeVlcf74Ua5EZejB-fNEILBKqWgncpg8KPLA-7983SKkNJcFAsLKvodViZ4SBpGDRf4B6TZ54RtDFus8P2mmKlxscc6DCHmD-idVT7Bx_19hO6_Xv-8uq3uvt98u7q8qzQjIlfcahAaDO-AWeDMrq1mvDWs7UjHhSmhawWkt0BKYt5ywsqPtjeMWdUJ0Ryh80V3mvstmLJgjsrLKbqtijsZlJOvX0Y3yE34LXkjCKtpEfi8F4jh1wwpy60rOb1XI4Q5yZrwljaUUV7Q0wXVMaQUwb7YUCKfG5SlQbk0WOCTfxd7Qf9WVoBPCxDm6X9CfwDJC6ly</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Lule, Swaib A</creator><creator>Namara, Benigna</creator><creator>Akurut, Helen</creator><creator>Muhangi, Lawrence</creator><creator>Lubyayi, Lawrence</creator><creator>Nampijja, Margaret</creator><creator>Akello, Florence</creator><creator>Tumusiime, Josephine</creator><creator>Aujo, Judith C</creator><creator>Oduru, Gloria</creator><creator>Smeeth, Liam</creator><creator>Elliott, Alison M</creator><creator>Webb, Emily L</creator><general>Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6271-2033</orcidid></search><sort><creationdate>20190201</creationdate><title>Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort</title><author>Lule, Swaib A ; Namara, Benigna ; Akurut, Helen ; Muhangi, Lawrence ; Lubyayi, Lawrence ; Nampijja, Margaret ; Akello, Florence ; Tumusiime, Josephine ; Aujo, Judith C ; Oduru, Gloria ; Smeeth, Liam ; Elliott, Alison M ; Webb, Emily L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-6fce8ced69e4fe64f5fc467d4790968d5772ae0bfe044967604fce7bd44fa9883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Birth Weight</topic><topic>Blood Pressure</topic><topic>Child</topic><topic>Child Development</topic><topic>Child, Preschool</topic><topic>Childhood Obesity and Weight Gain</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - epidemiology</topic><topic>Infant</topic><topic>Infant, Low Birth Weight - growth & development</topic><topic>Infant, Newborn</topic><topic>Linear Models</topic><topic>Male</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Uganda - epidemiology</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lule, Swaib A</creatorcontrib><creatorcontrib>Namara, Benigna</creatorcontrib><creatorcontrib>Akurut, Helen</creatorcontrib><creatorcontrib>Muhangi, Lawrence</creatorcontrib><creatorcontrib>Lubyayi, Lawrence</creatorcontrib><creatorcontrib>Nampijja, Margaret</creatorcontrib><creatorcontrib>Akello, Florence</creatorcontrib><creatorcontrib>Tumusiime, Josephine</creatorcontrib><creatorcontrib>Aujo, Judith C</creatorcontrib><creatorcontrib>Oduru, Gloria</creatorcontrib><creatorcontrib>Smeeth, Liam</creatorcontrib><creatorcontrib>Elliott, Alison M</creatorcontrib><creatorcontrib>Webb, Emily L</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lule, Swaib A</au><au>Namara, Benigna</au><au>Akurut, Helen</au><au>Muhangi, Lawrence</au><au>Lubyayi, Lawrence</au><au>Nampijja, Margaret</au><au>Akello, Florence</au><au>Tumusiime, Josephine</au><au>Aujo, Judith C</au><au>Oduru, Gloria</au><au>Smeeth, Liam</au><au>Elliott, Alison M</au><au>Webb, Emily L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort</atitle><jtitle>International journal of epidemiology</jtitle><addtitle>Int J Epidemiol</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>48</volume><issue>1</issue><spage>148</spage><epage>156</epage><pages>148-156</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Abstract
Background
In Africa, where low birthweight (LBW), malnutrition and high blood pressure (BP) are prevalent, the relationships between birthweight (BW), weight gain and BP later in life remain uncertain. We examined the effects of early life growth on BP among Ugandan adolescents.
Methods
Data were collected prenatally from women and their offspring were followed from birth, with BP measured following standard protocols in early adolescence. Weight-for-age Z-scores (WAZ) were computed using World Health Organization references. Linear regression was used to relate BW, and changes in WAZ between birth and 5 years, to adolescents’ BP, adjusting for confounders.
Results
Among 2345 live offspring, BP was measured in 1119 (47.7%) adolescents, with mean systolic BP 105.9 mmHg and mean diastolic BP 65.2 mmHg. There was little evidence of association between BW and systolic [regression coefficient β = 0.14, 95% confidence interval (CI) (-1.00, 1.27)] or diastolic [β = 0.43, 95% CI (-0.57, 1.43)] BP. Accelerated weight gain between birth and 5 years was associated with increased BP: systolic β = 1.17, 95% CI (0.69, 1.66) and diastolic β = 1.03, 95% CI (0.59, 1.47). Between birth and 6 months of age, effects of accelerated weight gain on adolescent BP were strongest among the LBW (both premature and small-for-gestational-age) children [BW < 2.5 kg: β = 2.64, 95% CI (0.91, 4.37), BW≥2.5 kg: β = 0.58, 95% CI (0.01, 1.14), interaction P-value = 0.024].
Conclusions
Findings from this large tropical birth cohort in Uganda suggest that postnatal weight gain rather than BW is important in the developmental programming of BP, with fast-growing LBW children at particular risk. Efforts to control BP should adopt a life course approach.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29982658</pmid><doi>10.1093/ije/dyy118</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6271-2033</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Birth Weight Blood Pressure Child Child Development Child, Preschool Childhood Obesity and Weight Gain Cohort Studies Female Humans Hypertension - epidemiology Infant Infant, Low Birth Weight - growth & development Infant, Newborn Linear Models Male Randomized Controlled Trials as Topic Uganda - epidemiology Weight Gain |
| title | Are birthweight and postnatal weight gain in childhood associated with blood pressure in early adolescence? Results from a Ugandan birth cohort |
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