Secondary Metabolites Profiling of Acinetobacter baumannii Associated with Chili (Capsicum annuum L.) Leaves and Concentration Dependent Antioxidant and Prooxidant Properties
Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant p...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-13 |
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| creator | Raju, Gunasunderi Bhore, Subhash Janardhan Rahman, Md. Sayedur Monowar, Tahmina Sathasivam, Kathiresan V. |
| description | Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE), and ethyl acetate (EA) crude extracts of the endophytic bacteria were studied. Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. Among the two phenolic compounds, namely, phenol, 2,4-bis(1,1-dimethylethyl)- and phenol, 3,5-bis(1,1-dimethylethyl)-, the former was found in abundance (11.56%) while the latter was found in smaller quantity (0.14%). Moreover, the endophytic bacteria was found to possess a number of metal ions including Fe(II) and Cu(II) as 1307.13 ± 2.35 ppb and 42.38 ± 0.352 ppb, respectively. The extracts exhibited concentration dependent antioxidant and prooxidant properties at high and low concentrations, respectively. The presence of phenolic compounds and metal ions was believed to play an important role in the antioxidant and prooxidant potentials of the extracts. Further studies are suggested for exploring the untapped resource of endophytic bacteria for the development of novel therapeutic agents. |
| doi_str_mv | 10.1155/2019/6951927 |
| format | Article |
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Leaves and Concentration Dependent Antioxidant and Prooxidant Properties</title><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Raju, Gunasunderi ; Bhore, Subhash Janardhan ; Rahman, Md. Sayedur ; Monowar, Tahmina ; Sathasivam, Kathiresan V.</creator><contributor>Tang, Kexuan</contributor><creatorcontrib>Raju, Gunasunderi ; Bhore, Subhash Janardhan ; Rahman, Md. Sayedur ; Monowar, Tahmina ; Sathasivam, Kathiresan V. ; Tang, Kexuan</creatorcontrib><description>Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE), and ethyl acetate (EA) crude extracts of the endophytic bacteria were studied. Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. Among the two phenolic compounds, namely, phenol, 2,4-bis(1,1-dimethylethyl)- and phenol, 3,5-bis(1,1-dimethylethyl)-, the former was found in abundance (11.56%) while the latter was found in smaller quantity (0.14%). Moreover, the endophytic bacteria was found to possess a number of metal ions including Fe(II) and Cu(II) as 1307.13 ± 2.35 ppb and 42.38 ± 0.352 ppb, respectively. The extracts exhibited concentration dependent antioxidant and prooxidant properties at high and low concentrations, respectively. The presence of phenolic compounds and metal ions was believed to play an important role in the antioxidant and prooxidant potentials of the extracts. Further studies are suggested for exploring the untapped resource of endophytic bacteria for the development of novel therapeutic agents.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/6951927</identifier><identifier>PMID: 30868071</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Abundance ; Acetic acid ; Acinetobacter baumannii ; Alkanes ; Alkenes ; Antioxidants ; Aromatic compounds ; Bacteria ; Bioactive compounds ; Biomolecules ; Cancer ; Capsicum annuum ; Carboxylic acids ; Cardiovascular disease ; Chelation ; Chemical compounds ; Chloroform ; Copper ; Diethyl ether ; Endophytes ; Esters ; Ethyl acetate ; Heterocyclic compounds ; Iron ; Ketones ; Lipids ; Low concentrations ; Metabolites ; Metal ions ; Oxidation ; Peppers ; Pharmacology ; Phenolic compounds ; Phenols ; Properties (attributes) ; Scavenging ; Secondary metabolites</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-13</ispartof><rights>Copyright © 2019 Tahmina Monowar et al.</rights><rights>Copyright © 2019 Tahmina Monowar et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Tahmina Monowar et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-a518be3ba4485f3af3e5f3ac0fd78a8ea1bd370d32a817fadd426d91944db87b3</citedby><cites>FETCH-LOGICAL-c471t-a518be3ba4485f3af3e5f3ac0fd78a8ea1bd370d32a817fadd426d91944db87b3</cites><orcidid>0000-0002-4894-2422 ; 0000-0002-6885-9562</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379878/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379878/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30868071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tang, Kexuan</contributor><creatorcontrib>Raju, Gunasunderi</creatorcontrib><creatorcontrib>Bhore, Subhash Janardhan</creatorcontrib><creatorcontrib>Rahman, Md. Sayedur</creatorcontrib><creatorcontrib>Monowar, Tahmina</creatorcontrib><creatorcontrib>Sathasivam, Kathiresan V.</creatorcontrib><title>Secondary Metabolites Profiling of Acinetobacter baumannii Associated with Chili (Capsicum annuum L.) Leaves and Concentration Dependent Antioxidant and Prooxidant Properties</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE), and ethyl acetate (EA) crude extracts of the endophytic bacteria were studied. Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. Among the two phenolic compounds, namely, phenol, 2,4-bis(1,1-dimethylethyl)- and phenol, 3,5-bis(1,1-dimethylethyl)-, the former was found in abundance (11.56%) while the latter was found in smaller quantity (0.14%). Moreover, the endophytic bacteria was found to possess a number of metal ions including Fe(II) and Cu(II) as 1307.13 ± 2.35 ppb and 42.38 ± 0.352 ppb, respectively. The extracts exhibited concentration dependent antioxidant and prooxidant properties at high and low concentrations, respectively. The presence of phenolic compounds and metal ions was believed to play an important role in the antioxidant and prooxidant potentials of the extracts. Further studies are suggested for exploring the untapped resource of endophytic bacteria for the development of novel therapeutic agents.</description><subject>Abundance</subject><subject>Acetic acid</subject><subject>Acinetobacter baumannii</subject><subject>Alkanes</subject><subject>Alkenes</subject><subject>Antioxidants</subject><subject>Aromatic compounds</subject><subject>Bacteria</subject><subject>Bioactive compounds</subject><subject>Biomolecules</subject><subject>Cancer</subject><subject>Capsicum annuum</subject><subject>Carboxylic acids</subject><subject>Cardiovascular disease</subject><subject>Chelation</subject><subject>Chemical compounds</subject><subject>Chloroform</subject><subject>Copper</subject><subject>Diethyl ether</subject><subject>Endophytes</subject><subject>Esters</subject><subject>Ethyl acetate</subject><subject>Heterocyclic compounds</subject><subject>Iron</subject><subject>Ketones</subject><subject>Lipids</subject><subject>Low concentrations</subject><subject>Metabolites</subject><subject>Metal ions</subject><subject>Oxidation</subject><subject>Peppers</subject><subject>Pharmacology</subject><subject>Phenolic compounds</subject><subject>Phenols</subject><subject>Properties (attributes)</subject><subject>Scavenging</subject><subject>Secondary metabolites</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEolXpjTOyxKUItrXjJHYuSKtQPqRFIAHnaBJPuq4Se7GdFv4Uv7Gz2u3yccKXmbGfeTXjmSx7Kvi5EGV5kXNRX1R1KepcPciOcymKRSUK8fDgS3mUncZ4zeloUfG6epwdSa4rzZU4zn59wd47A-En-4gJOj_ahJF9Dn6wo3VXzA9s2VuHyXfQJwysg3kC56xlyxh9byGhYbc2rVmzphR21sAm2n6eGFEzmdX5C7ZCuCFZcIY13vXoUoBkvWNvcIPOUMyWji5-WAPkbzkq4T4kd4MhWYxPskcDjBFP9_Yk-_b28mvzfrH69O5Ds1wt-kKJtIBS6A5lB0Why0HCIHFrej4YpUEjiM5IxY3MQQs1gDFFXpla1EVhOq06eZK93ulu5m5Csyt4bDfBTvRVrQfb_v3i7Lq98jdtJVWtlSaBs71A8N9njKmdbOxxHMGhn2Obi1rIsqR5EPr8H_Taz8FRe0TpvMylkgVRr3ZUH3yMAYdDMYK3211ot7vQ7neB8Gd_NnCA7ydPwMsdsLY0_lv7n3JIDA7wmxa54pLLO1H2yio</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Raju, Gunasunderi</creator><creator>Bhore, Subhash Janardhan</creator><creator>Rahman, Md. 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Leaves and Concentration Dependent Antioxidant and Prooxidant Properties</title><author>Raju, Gunasunderi ; Bhore, Subhash Janardhan ; Rahman, Md. Sayedur ; Monowar, Tahmina ; Sathasivam, Kathiresan V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-a518be3ba4485f3af3e5f3ac0fd78a8ea1bd370d32a817fadd426d91944db87b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abundance</topic><topic>Acetic acid</topic><topic>Acinetobacter baumannii</topic><topic>Alkanes</topic><topic>Alkenes</topic><topic>Antioxidants</topic><topic>Aromatic compounds</topic><topic>Bacteria</topic><topic>Bioactive compounds</topic><topic>Biomolecules</topic><topic>Cancer</topic><topic>Capsicum annuum</topic><topic>Carboxylic acids</topic><topic>Cardiovascular disease</topic><topic>Chelation</topic><topic>Chemical compounds</topic><topic>Chloroform</topic><topic>Copper</topic><topic>Diethyl ether</topic><topic>Endophytes</topic><topic>Esters</topic><topic>Ethyl acetate</topic><topic>Heterocyclic compounds</topic><topic>Iron</topic><topic>Ketones</topic><topic>Lipids</topic><topic>Low concentrations</topic><topic>Metabolites</topic><topic>Metal ions</topic><topic>Oxidation</topic><topic>Peppers</topic><topic>Pharmacology</topic><topic>Phenolic compounds</topic><topic>Phenols</topic><topic>Properties (attributes)</topic><topic>Scavenging</topic><topic>Secondary metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raju, Gunasunderi</creatorcontrib><creatorcontrib>Bhore, Subhash Janardhan</creatorcontrib><creatorcontrib>Rahman, Md. 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Sayedur</au><au>Monowar, Tahmina</au><au>Sathasivam, Kathiresan V.</au><au>Tang, Kexuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary Metabolites Profiling of Acinetobacter baumannii Associated with Chili (Capsicum annuum L.) Leaves and Concentration Dependent Antioxidant and Prooxidant Properties</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE), and ethyl acetate (EA) crude extracts of the endophytic bacteria were studied. Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. Among the two phenolic compounds, namely, phenol, 2,4-bis(1,1-dimethylethyl)- and phenol, 3,5-bis(1,1-dimethylethyl)-, the former was found in abundance (11.56%) while the latter was found in smaller quantity (0.14%). Moreover, the endophytic bacteria was found to possess a number of metal ions including Fe(II) and Cu(II) as 1307.13 ± 2.35 ppb and 42.38 ± 0.352 ppb, respectively. The extracts exhibited concentration dependent antioxidant and prooxidant properties at high and low concentrations, respectively. The presence of phenolic compounds and metal ions was believed to play an important role in the antioxidant and prooxidant potentials of the extracts. Further studies are suggested for exploring the untapped resource of endophytic bacteria for the development of novel therapeutic agents.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30868071</pmid><doi>10.1155/2019/6951927</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-4894-2422</orcidid><orcidid>https://orcid.org/0000-0002-6885-9562</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abundance Acetic acid Acinetobacter baumannii Alkanes Alkenes Antioxidants Aromatic compounds Bacteria Bioactive compounds Biomolecules Cancer Capsicum annuum Carboxylic acids Cardiovascular disease Chelation Chemical compounds Chloroform Copper Diethyl ether Endophytes Esters Ethyl acetate Heterocyclic compounds Iron Ketones Lipids Low concentrations Metabolites Metal ions Oxidation Peppers Pharmacology Phenolic compounds Phenols Properties (attributes) Scavenging Secondary metabolites |
| title | Secondary Metabolites Profiling of Acinetobacter baumannii Associated with Chili (Capsicum annuum L.) Leaves and Concentration Dependent Antioxidant and Prooxidant Properties |
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