IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

IL-17A is a critical proinflammatory cytokine for the pathogenesis of asthma including neutrophilic pulmonary inflammation and airway hyperresponsiveness. In this study, by cell type-specific deletion of IL-17R and adaptor Act1, we demonstrated that IL-17R/Act1 exerts a direct impact on the contract...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-03, Vol.202 (5), p.1540-1548
Hauptverfasser:	Bulek, Katarzyna, Chen, Xing, Parron, Vandy, Sundaram, Aparna, Herjan, Tomasz, Ouyang, Suidong, Liu, Caini, Majors, Alana, Zepp, Jarod, Gao, Ji, Dongre, Ashok, Bodaszewska-Lubas, Malgorzata, Echard, Arnaud, Aronica, Mark, Carman, Julie, Garantziotis, Stavros, Sheppard, Dean, Li, Xiaoxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Cancer Cellular Biology Immunology Innate Immunity and Inflammation Interleukin-17 - antagonists & inhibitors Interleukin-17 - deficiency Interleukin-17 - metabolism Life Sciences Mice Mice, Knockout Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Protein Kinase C-alpha - antagonists & inhibitors Protein Kinase C-alpha - metabolism Protein Kinase Inhibitors - pharmacology rab GTP-Binding Proteins - antagonists & inhibitors rab GTP-Binding Proteins - metabolism Receptors, Interleukin-17 - antagonists & inhibitors Receptors, Interleukin-17 - metabolism Stress Fibers - drug effects Stress Fibers - metabolism
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