H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis

Cholestasis induces the hepatic long non-coding RNA H19, which promotes the progression of cholestatic liver fibrosis. However, microRNAs that are dysregulated by H19 during cholestasis remain elusive. Using miRNA-sequencing analysis followed by qPCR validation, we identified marked upregulation of...

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Veröffentlicht in:	Cell death & disease 2019-02, Vol.10 (3), p.168-168, Article 168
Hauptverfasser:	Zhang, Li, Yang, Zhihong, Huang, Wendong, Wu, Jianguo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/89 38/39 38/77 38/90 38/91 631/337/384/2568 631/337/384/331 631/45/500 64/60 692/308/1426 96/21 Animals Antibodies Bile Bile Acids and Salts - metabolism Bile ducts Bile Ducts - pathology Bioavailability Biochemistry Bioinformatics Biomedical and Life Sciences Cell Biology Cell Culture Cholestasis Disease Models, Animal Fibrosis Gallbladder diseases Hepatocytes - metabolism Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism Immunology Immunoprecipitation Life Sciences Liver Liver - metabolism Liver - pathology Liver Cirrhosis, Biliary - genetics Liver Cirrhosis, Biliary - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs - metabolism miRNA Non-coding RNA Polypyrimidine tract-binding protein Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Proteins RNA, Long Noncoding - metabolism RNA-binding protein
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