Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus
Objective It is important to preserve the pancreatic β-cell function in order to maintain good glycemic control for a long period. The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects wit...
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| Veröffentlicht in: | Internal Medicine 2019/01/15, Vol.58(2), pp.167-173 |
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| creator | Takai, Maiko Anno, Takatoshi Kawasaki, Fumiko Kimura, Tomohiko Hirukawa, Hidenori Mune, Tomoatsu Okimoto, Niro Kaku, Kohei Kaneto, Hideaki |
| description | Objective It is important to preserve the pancreatic β-cell function in order to maintain good glycemic control for a long period. The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects with type 2 diabetes who had been hospitalized for the amelioration of their glycemic control and/or education about diabetes in Kawasaki Medical School Hospital were included in this study. We evaluated the remnant β-cell function as the HOMA-%β using the computer software program HOMA2 and estimated the glycemic fluctuation with the glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio. In addition, we divided the subjects into a relatively young group ( |
| doi_str_mv | 10.2169/internalmedicine.1053-18 |
| format | Article |
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The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects with type 2 diabetes who had been hospitalized for the amelioration of their glycemic control and/or education about diabetes in Kawasaki Medical School Hospital were included in this study. We evaluated the remnant β-cell function as the HOMA-%β using the computer software program HOMA2 and estimated the glycemic fluctuation with the glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio. In addition, we divided the subjects into a relatively young group (<65 years old) (n=210) and an elderly group (≥65 years old) (n=162) and performed several analyses in each group. Results The GA/HbA1c ratio, GA and HbA1c were independent determinant factors for the HOMA-%β regardless of age. We obtained almost the same results even after excluding those subjects using insulin secretagogues. These data suggest that the glycemic fluctuation and glycemic control are associated with the remnant β-cell function in Japanese subjects with type 2 diabetes. Conclusion It is very important to reduce glycemic fluctuation as well as to maintain good glycemic control in order to preserve β-cell function in subjects with type 2 diabetes.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1053-18</identifier><identifier>PMID: 30146574</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Age Factors ; Aged ; Blood Glucose - metabolism ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - pathology ; Female ; fluctuation of the blood glucose levels ; Geriatrics ; Glucose ; Glycated Hemoglobin A - metabolism ; Hemoglobin ; Humans ; Insulin ; Insulin-Secreting Cells - physiology ; Internal medicine ; Male ; Middle Aged ; Older people ; Original ; Pancreas ; pancreatic β-cell function ; Serum Albumin - metabolism ; type 2 diabetes mellitus ; Variation</subject><ispartof>Internal Medicine, 2019/01/15, Vol.58(2), pp.167-173</ispartof><rights>2019 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2019</rights><rights>Copyright © 2019 by The Japanese Society of Internal Medicine 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-db6999c4278ee9e45740a6790b23559e1cce2942d604874e6db153193742ec4d3</citedby><cites>FETCH-LOGICAL-c609t-db6999c4278ee9e45740a6790b23559e1cce2942d604874e6db153193742ec4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378157/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378157/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30146574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takai, Maiko</creatorcontrib><creatorcontrib>Anno, Takatoshi</creatorcontrib><creatorcontrib>Kawasaki, Fumiko</creatorcontrib><creatorcontrib>Kimura, Tomohiko</creatorcontrib><creatorcontrib>Hirukawa, Hidenori</creatorcontrib><creatorcontrib>Mune, Tomoatsu</creatorcontrib><creatorcontrib>Okimoto, Niro</creatorcontrib><creatorcontrib>Kaku, Kohei</creatorcontrib><creatorcontrib>Kaneto, Hideaki</creatorcontrib><title>Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective It is important to preserve the pancreatic β-cell function in order to maintain good glycemic control for a long period. The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects with type 2 diabetes who had been hospitalized for the amelioration of their glycemic control and/or education about diabetes in Kawasaki Medical School Hospital were included in this study. We evaluated the remnant β-cell function as the HOMA-%β using the computer software program HOMA2 and estimated the glycemic fluctuation with the glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio. In addition, we divided the subjects into a relatively young group (<65 years old) (n=210) and an elderly group (≥65 years old) (n=162) and performed several analyses in each group. Results The GA/HbA1c ratio, GA and HbA1c were independent determinant factors for the HOMA-%β regardless of age. We obtained almost the same results even after excluding those subjects using insulin secretagogues. These data suggest that the glycemic fluctuation and glycemic control are associated with the remnant β-cell function in Japanese subjects with type 2 diabetes. Conclusion It is very important to reduce glycemic fluctuation as well as to maintain good glycemic control in order to preserve β-cell function in subjects with type 2 diabetes.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Female</subject><subject>fluctuation of the blood glucose levels</subject><subject>Geriatrics</subject><subject>Glucose</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin-Secreting Cells - physiology</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Original</subject><subject>Pancreas</subject><subject>pancreatic β-cell function</subject><subject>Serum Albumin - metabolism</subject><subject>type 2 diabetes mellitus</subject><subject>Variation</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplks1u1DAUhSMEokPhFZAlNmxS_Jc43iBVU6aAyo9EWVuOc6fjUcYebIdqnoW34EF4JpxmiKBsfBf3O8c-vrcoEMFnlNTylXUJgtP9DjprrIMzgitWkuZBsSCMy1JQVj0sFliSpqT5OCmexLjFmDVC0sfFCcOE15Xgi-LHeYzeWJ2sd8ivUdoAuuwPBnbWoFU_mDRMPR3RLfT9WOf-0rsUfI9ubdrcKT9rZwJkgUG_fpZm5FeDM3cG1qH3eq8dREBfhnYLJsVJeX3YA6LowuoWEkT0IetsGuLT4tFa9xGeHetp8XX15nr5trz6dPlueX5VmhrLVHZtLaU0nIoGQALPubCuhcRt_oVKAjEGqOS0qzFvBIe6a0nFiGSCUzC8Y6fF68l3P7T5Rw3kVLpX-2B3OhyU11b923F2o278d1Uz0ZBKZIOXR4Pgvw0Qk9rZOKbPaf0QFcWScyI4YRl9cQ_d-mEcZaYor2UOQUimmokywccYYD0_hmA1boC6vwFq3ABFmix9_neYWfhn5Bn4OAHbmPQNzIAOeWw9_O9cNYqOx_GGGTQbHRQ49hufS9Hh</recordid><startdate>20190115</startdate><enddate>20190115</enddate><creator>Takai, Maiko</creator><creator>Anno, Takatoshi</creator><creator>Kawasaki, Fumiko</creator><creator>Kimura, Tomohiko</creator><creator>Hirukawa, Hidenori</creator><creator>Mune, Tomoatsu</creator><creator>Okimoto, Niro</creator><creator>Kaku, Kohei</creator><creator>Kaneto, Hideaki</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190115</creationdate><title>Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus</title><author>Takai, Maiko ; Anno, Takatoshi ; Kawasaki, Fumiko ; Kimura, Tomohiko ; Hirukawa, Hidenori ; Mune, Tomoatsu ; Okimoto, Niro ; Kaku, Kohei ; Kaneto, Hideaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-db6999c4278ee9e45740a6790b23559e1cce2942d604874e6db153193742ec4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Female</topic><topic>fluctuation of the blood glucose levels</topic><topic>Geriatrics</topic><topic>Glucose</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin-Secreting Cells - physiology</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Original</topic><topic>Pancreas</topic><topic>pancreatic β-cell function</topic><topic>Serum Albumin - metabolism</topic><topic>type 2 diabetes mellitus</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takai, Maiko</creatorcontrib><creatorcontrib>Anno, Takatoshi</creatorcontrib><creatorcontrib>Kawasaki, Fumiko</creatorcontrib><creatorcontrib>Kimura, Tomohiko</creatorcontrib><creatorcontrib>Hirukawa, Hidenori</creatorcontrib><creatorcontrib>Mune, Tomoatsu</creatorcontrib><creatorcontrib>Okimoto, Niro</creatorcontrib><creatorcontrib>Kaku, Kohei</creatorcontrib><creatorcontrib>Kaneto, Hideaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takai, Maiko</au><au>Anno, Takatoshi</au><au>Kawasaki, Fumiko</au><au>Kimura, Tomohiko</au><au>Hirukawa, Hidenori</au><au>Mune, Tomoatsu</au><au>Okimoto, Niro</au><au>Kaku, Kohei</au><au>Kaneto, Hideaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2019-01-15</date><risdate>2019</risdate><volume>58</volume><issue>2</issue><spage>167</spage><epage>173</epage><pages>167-173</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective It is important to preserve the pancreatic β-cell function in order to maintain good glycemic control for a long period. The aim of this study was to examine which factors are associated with the β-cell function in subjects with type 2 diabetes mellitus. Methods A total of 372 subjects with type 2 diabetes who had been hospitalized for the amelioration of their glycemic control and/or education about diabetes in Kawasaki Medical School Hospital were included in this study. We evaluated the remnant β-cell function as the HOMA-%β using the computer software program HOMA2 and estimated the glycemic fluctuation with the glycoalbumin (GA)/hemoglobin A1c (HbA1c) ratio. In addition, we divided the subjects into a relatively young group (<65 years old) (n=210) and an elderly group (≥65 years old) (n=162) and performed several analyses in each group. Results The GA/HbA1c ratio, GA and HbA1c were independent determinant factors for the HOMA-%β regardless of age. We obtained almost the same results even after excluding those subjects using insulin secretagogues. These data suggest that the glycemic fluctuation and glycemic control are associated with the remnant β-cell function in Japanese subjects with type 2 diabetes. Conclusion It is very important to reduce glycemic fluctuation as well as to maintain good glycemic control in order to preserve β-cell function in subjects with type 2 diabetes.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>30146574</pmid><doi>10.2169/internalmedicine.1053-18</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Blood Glucose - metabolism Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - pathology Female fluctuation of the blood glucose levels Geriatrics Glucose Glycated Hemoglobin A - metabolism Hemoglobin Humans Insulin Insulin-Secreting Cells - physiology Internal medicine Male Middle Aged Older people Original Pancreas pancreatic β-cell function Serum Albumin - metabolism type 2 diabetes mellitus Variation |
| title | Association of the Glycemic Fluctuation as well as Glycemic Control with the Pancreatic β-cell Function in Japanese Subjects with Type 2 Diabetes Mellitus |
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