Clinical Features and Therapeutic Outcomes in Men with Advanced Prostate Cancer and DNA Mismatch Repair Gene Mutations

Mismatch repair (MMR) gene mutations are rare in prostate cancer, and their histological and clinical characteristics are largely unknown. We conducted a retrospective study to explore disease characteristics and treatment outcomes of men with metastatic prostate cancer harboring germline and/or som...

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Veröffentlicht in:	European urology 2019-03, Vol.75 (3), p.378-382
Hauptverfasser:	Antonarakis, Emmanuel S., Shaukat, Farah, Isaacsson Velho, Pedro, Kaur, Harsimar, Shenderov, Eugene, Pardoll, Drew M., Lotan, Tamara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers, Tumor - genetics Databases, Factual DNA Mismatch Repair - genetics Genetic Predisposition to Disease Humans Male Microsatellite instability Middle Aged Mismatch repair MSH2 MSH6 Mutation Neoplasm Grading Phenotype Progression-Free Survival Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Retrospective Studies Time Factors
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