Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer

Long noncoding RNAs (lncRNAs) are implicated in renal cell carcinoma (RCC), but remain largely unclear. Using publicly available transcriptome sequencing data from renal cancer ( n = 703) and integrating bioinformatics analyses, we screened and identified a valuable lncRNA, EGFR-AS1. In our validat...

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Veröffentlicht in:	Cell death & disease 2019-02, Vol.10 (3), p.154-154, Article 154
Hauptverfasser:	Wang, Anbang, Bao, Yi, Wu, Zhenjie, Zhao, Tangliang, Wang, Dong, Shi, Jiazi, Liu, Bing, Sun, Shuhan, Yang, Fu, Wang, Linhui, Qu, Le
Format:	Artikel
Sprache:	eng
Schlagworte:	38/32 631/67/1059/153 631/67/589/1588/1351 64/60 82/80 Antibodies Biochemistry Bioinformatics Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Cell Biology Cell Culture Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Complementarity ELAV-Like Protein 1 - metabolism Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Female Follow-Up Studies Gene expression Gene Knockdown Techniques Humans HuR protein Immunology Kidney cancer Kidney Neoplasms - metabolism Kidney Neoplasms - mortality Kidney Neoplasms - pathology Life Sciences Male Mass spectroscopy Metastases Middle Aged mRNA stability Multivariate analysis Neoplasm Invasiveness - genetics Neoplasm Metastasis - genetics Phenotypes Prognosis Renal cell carcinoma RNA Interference RNA Stability - genetics RNA, Long Noncoding - genetics RNA, Messenger - metabolism Survival Rate Therapeutic applications Transfection Up-Regulation
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