MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer

The global morbidity and mortality of colorectal cancer (CRC) are ranked the third among gastrointestinal tumors in the world. MiR-451a is associated with several types of cancer, including CRC. However, the roles and mechanisms of miR-451a in CRC have not been elucidated. BAP31 is a predicted targe...

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Veröffentlicht in:	Cell death & disease 2019-02, Vol.10 (3), p.152, Article 152
Hauptverfasser:	Xu, Ke, Han, Bin, Bai, Yang, Ma, Xiu-Ying, Ji, Zhen-Ni, Xiong, Yao, Miao, Shi-Kun, Zhang, Yuan-Yuan, Zhou, Li-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/34 38/77 5' Untranslated Regions 631/80/304 631/80/82/23 64/60 96/2 Animals Antibodies Apoptosis Apoptosis - genetics BAP31 protein Bax protein Binding Sites Biochemistry Biomedical and Life Sciences Calcium Cell Biology Cell Culture Cell proliferation Cell Proliferation - genetics Cohort Studies Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Endoplasmic Reticulum Stress - genetics Epithelial cells Female Gene Expression Regulation, Neoplastic - genetics HCT116 Cells HEK293 Cells Heterografts HT29 Cells Humans Hybridization Immunohistochemistry Immunology Life Sciences Male Membrane Proteins - genetics Membrane Proteins - metabolism Metastases Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged Morbidity Transfection Tumor Burden - genetics Tumors
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