Ferroptosis as a target for protection against cardiomyopathy

Heart disease is the leading cause of death worldwide. A key pathogenic factor in the development of lethal heart failure is loss of terminally differentiated cardiomyocytes. However, mechanisms of cardiomyocyte death remain unclear. Here, we discovered and demonstrated that ferroptosis, a programme...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-02, Vol.116 (7), p.2672-2680
Hauptverfasser:	Fang, Xuexian, Wang, Hao, Han, Dan, Xie, Enjun, Yang, Xiang, Wei, Jiayu, Gu, Shanshan, Gao, Feng, Zhu, Nali, Yin, Xiangju, Cheng, Qi, Zhang, Pan, Dai, Wei, Chen, Jinghai, Yang, Fuquan, Yang, Huang-Tian, Linkermann, Andreas, Gu, Wei, Min, Junxia, Wang, Fudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antioxidants Apoptosis Biological Sciences Cardiomyocytes Cardiomyopathies - chemically induced Cardiomyopathies - prevention & control Cardiomyopathy Cardiotoxicity Cardiovascular diseases Cell death Chelation Congestive heart failure Coronary artery disease Damage Degradation Doxorubicin Doxorubicin - pharmacology Doxorubicin - toxicity FADD protein Ferroptosis Gene sequencing Heart diseases Heart failure Heme Heme - metabolism Heme oxygenase (decyclizing) Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Iron Iron - metabolism Ischemia Lipid membranes Lipid Peroxidation Lipids Membranes Mice Mice, Knockout Mitochondria Mitochondria, Heart - drug effects Mitochondria, Heart - enzymology Mitochondria, Heart - metabolism Mortality Myocytes, Cardiac - metabolism Necroptosis NF-E2-Related Factor 2 - genetics Oxygenase Peroxidation PNAS Plus Protoporphyrin Protoporphyrin IX Razoxane Reperfusion Reperfusion Injury - prevention & control Ribonucleic acid RNA Up-Regulation Zinc Zinc protoporphyrin IX
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