Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors
The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland ( B . burgdorferi s.l., A . phagocytophilum , Ehrlichia spp., Babesia spp., Rickettsia spp. Bartonella henselae ) to assess the frequency of exposure...
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| Veröffentlicht in: | Scientific reports 2019-02, Vol.9 (1), p.2117-2117, Article 2117 |
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| creator | Pawełczyk, Agnieszka Bednarska, Małgorzata Kowalska, Justyna D. Uszyńska-Kałuża, Beata Radkowski, Marek Welc-Falęciak, Renata |
| description | The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (
B
.
burgdorferi
s.l.,
A
.
phagocytophilum
,
Ehrlichia
spp.,
Babesia
spp.,
Rickettsia
spp.
Bartonella henselae
) to assess the frequency of exposure to such microorganisms in immunocompetent and immunocompromised individuals in endemic regions for
I
.
ricinus
ticks. Serum samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between two tested group as well as age, sex and lymphocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is higher than that of the healthy population in Poland, although no association between serological status of patients and lymphocyte CD4+ T cell level has been observed. The frequency of tick-borne coinfections and doubtful results of serological tests were significantly higher in HIV-positive individuals. In Poland, the possibility of tick-borne diseases transmission with blood is rather negligible. |
| doi_str_mv | 10.1038/s41598-019-38755-9 |
| format | Article |
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B
.
burgdorferi
s.l.,
A
.
phagocytophilum
,
Ehrlichia
spp.,
Babesia
spp.,
Rickettsia
spp.
Bartonella henselae
) to assess the frequency of exposure to such microorganisms in immunocompetent and immunocompromised individuals in endemic regions for
I
.
ricinus
ticks. Serum samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between two tested group as well as age, sex and lymphocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is higher than that of the healthy population in Poland, although no association between serological status of patients and lymphocyte CD4+ T cell level has been observed. The frequency of tick-borne coinfections and doubtful results of serological tests were significantly higher in HIV-positive individuals. In Poland, the possibility of tick-borne diseases transmission with blood is rather negligible.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-38755-9</identifier><identifier>PMID: 30765826</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/255/1715 ; 692/699/255/1901 ; 82/1 ; 82/51 ; Arachnids ; Blood ; Blood & organ donations ; Blood donors ; CD4 antigen ; Disease transmission ; Health risk assessment ; HIV ; Human immunodeficiency virus ; Humanities and Social Sciences ; Lymphocytes ; Lymphocytes T ; Microorganisms ; multidisciplinary ; Pathogens ; Science ; Science (multidisciplinary) ; Serological tests ; Sexually transmitted diseases ; STD ; Tick-borne diseases</subject><ispartof>Scientific reports, 2019-02, Vol.9 (1), p.2117-2117, Article 2117</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-bc9e80faf99df0d3ab8fb0b26593d352d3aa38726e6b582c71f47cf7be4c53ef3</citedby><cites>FETCH-LOGICAL-c474t-bc9e80faf99df0d3ab8fb0b26593d352d3aa38726e6b582c71f47cf7be4c53ef3</cites><orcidid>0000-0003-2266-1435</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376038/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376038/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,41099,42168,51554,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30765826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pawełczyk, Agnieszka</creatorcontrib><creatorcontrib>Bednarska, Małgorzata</creatorcontrib><creatorcontrib>Kowalska, Justyna D.</creatorcontrib><creatorcontrib>Uszyńska-Kałuża, Beata</creatorcontrib><creatorcontrib>Radkowski, Marek</creatorcontrib><creatorcontrib>Welc-Falęciak, Renata</creatorcontrib><title>Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (
B
.
burgdorferi
s.l.,
A
.
phagocytophilum
,
Ehrlichia
spp.,
Babesia
spp.,
Rickettsia
spp.
Bartonella henselae
) to assess the frequency of exposure to such microorganisms in immunocompetent and immunocompromised individuals in endemic regions for
I
.
ricinus
ticks. Serum samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between two tested group as well as age, sex and lymphocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is higher than that of the healthy population in Poland, although no association between serological status of patients and lymphocyte CD4+ T cell level has been observed. The frequency of tick-borne coinfections and doubtful results of serological tests were significantly higher in HIV-positive individuals. In Poland, the possibility of tick-borne diseases transmission with blood is rather negligible.</description><subject>692/699/255/1715</subject><subject>692/699/255/1901</subject><subject>82/1</subject><subject>82/51</subject><subject>Arachnids</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood donors</subject><subject>CD4 antigen</subject><subject>Disease transmission</subject><subject>Health risk assessment</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humanities and Social Sciences</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Microorganisms</subject><subject>multidisciplinary</subject><subject>Pathogens</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Serological tests</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Tick-borne diseases</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2PFCEQhjtG427W_QMeDIkXL6000B9cTMxG3Uk28eDHldBQzLB2wwj0uPMX_NXWOOu6epALUPXUC1VvVT1t6MuG8uFVFk0rh5o2suZD37a1fFCdMiramnHGHt47n1TnOV9TXC2TopGPqxNO-64dWHda_fgIKW4T7PQEwQCJjmR_Q7a6bOIaQiYl6ZBnXwpYMu5J2QBZ3UQLmSRvfFiQ8OZrJj4QnffztsRZYwTv1u-8XfSUyXdfNuRy9QWDDkzxEdlgDyXjFKMlNoaY8pPqkUMazm_3s-rzu7efLi7rqw_vVxdvrmojelHq0UgYqNNOSuuo5Xoc3EhH1rWSW94yjGicCOugG7FH0zdO9Mb1IwjTcnD8rHp91N0u4wzWQMAeJ7VNftZpr6L26u9M8Bu1jjvV8b7D0aPAi1uBFL8tkIuafTYwTTpAXLJizSAaIbjsEX3-D3odlxSwvQNF5cBaypBiR8qkmHMCd_eZhqqD2-rotkK31S-3lcSiZ_fbuCv57S0C_AhkTIU1pD9v_0f2J-jbuak</recordid><startdate>20190214</startdate><enddate>20190214</enddate><creator>Pawełczyk, Agnieszka</creator><creator>Bednarska, Małgorzata</creator><creator>Kowalska, Justyna D.</creator><creator>Uszyńska-Kałuża, Beata</creator><creator>Radkowski, Marek</creator><creator>Welc-Falęciak, Renata</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2266-1435</orcidid></search><sort><creationdate>20190214</creationdate><title>Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors</title><author>Pawełczyk, Agnieszka ; Bednarska, Małgorzata ; Kowalska, Justyna D. ; Uszyńska-Kałuża, Beata ; Radkowski, Marek ; Welc-Falęciak, Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-bc9e80faf99df0d3ab8fb0b26593d352d3aa38726e6b582c71f47cf7be4c53ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>692/699/255/1715</topic><topic>692/699/255/1901</topic><topic>82/1</topic><topic>82/51</topic><topic>Arachnids</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood donors</topic><topic>CD4 antigen</topic><topic>Disease transmission</topic><topic>Health risk assessment</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humanities and Social Sciences</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Microorganisms</topic><topic>multidisciplinary</topic><topic>Pathogens</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serological tests</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Tick-borne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawełczyk, Agnieszka</creatorcontrib><creatorcontrib>Bednarska, Małgorzata</creatorcontrib><creatorcontrib>Kowalska, Justyna D.</creatorcontrib><creatorcontrib>Uszyńska-Kałuża, Beata</creatorcontrib><creatorcontrib>Radkowski, Marek</creatorcontrib><creatorcontrib>Welc-Falęciak, Renata</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawełczyk, Agnieszka</au><au>Bednarska, Małgorzata</au><au>Kowalska, Justyna D.</au><au>Uszyńska-Kałuża, Beata</au><au>Radkowski, Marek</au><au>Welc-Falęciak, Renata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-02-14</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>2117</spage><epage>2117</epage><pages>2117-2117</pages><artnum>2117</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The objective of our study was to estimate the seroprevalence of six pathogens transmitted by ticks in HIV-infected persons and blood donors in Poland (
B
.
burgdorferi
s.l.,
A
.
phagocytophilum
,
Ehrlichia
spp.,
Babesia
spp.,
Rickettsia
spp.
Bartonella henselae
) to assess the frequency of exposure to such microorganisms in immunocompetent and immunocompromised individuals in endemic regions for
I
.
ricinus
ticks. Serum samples were collected from 227 HIV-infected patients and 199 blood donors. All samples were analyzed for antibodies against six tick-borne pathogens and seroprevalence rates were statistically compared between two tested group as well as age, sex and lymphocyte T CD4+ level in HIV infected patients. The seroprevalence of tick-borne infections in HIV-infected patients is higher than that of the healthy population in Poland, although no association between serological status of patients and lymphocyte CD4+ T cell level has been observed. The frequency of tick-borne coinfections and doubtful results of serological tests were significantly higher in HIV-positive individuals. In Poland, the possibility of tick-borne diseases transmission with blood is rather negligible.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30765826</pmid><doi>10.1038/s41598-019-38755-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2266-1435</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Nature Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 692/699/255/1715 692/699/255/1901 82/1 82/51 Arachnids Blood Blood & organ donations Blood donors CD4 antigen Disease transmission Health risk assessment HIV Human immunodeficiency virus Humanities and Social Sciences Lymphocytes Lymphocytes T Microorganisms multidisciplinary Pathogens Science Science (multidisciplinary) Serological tests Sexually transmitted diseases STD Tick-borne diseases |
| title | Seroprevalence of six pathogens transmitted by the Ixodes ricinus ticks in asymptomatic individuals with HIV infection and in blood donors |
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