The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis

Immune-mediated glomerular diseases like crescentic glomerulonephritis (cGN) are driven by inappropriately regulated cellular and humoral immune responses subsequently leading to renal tissue injury. Recent studies demonstrated the crucial role for regulatory T cells (Tregs) in suppressing pathogeni...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2038, Article 2038
Hauptverfasser:	Neumann, Katrin, Ostmann, Annett, Breda, Philippe Christophe, Ochel, Aaron, Tacke, Frank, Paust, Hans-Joachim, Panzer, Ulf, Tiegs, Gisa
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 38/61 38/77 631/250/2152/569/2495 631/250/256/2516 64/60 82/1 Animal models Foxp3 protein Gene expression Glomerulonephritis Homeostasis Humanities and Social Sciences Immune response Immune response (humoral) Immunoregulation Inflammation Kidneys Lymphocytes T multidisciplinary Nephritis PD-1 protein PD-L1 protein Rodents Science Science (multidisciplinary) Signal transduction γ-Interferon
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