Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome

Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes....

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.2138-2138, Article 2138
Hauptverfasser:	Singhal, Megha, Turturice, Benjamin A., Manzella, Christopher R., Ranjan, Ravi, Metwally, Ahmed A., Theorell, Juliana, Huang, Yue, Alrefai, Waddah A., Dudeja, Pradeep K., Finn, Patricia W., Perkins, David L., Gill, Ravinder K.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/22 38/23 38/39 38/77 38/90 631/326/2565/2134 64/60 692/699/317 Animals Bacilli Bacteria - classification Bacteria - genetics Bacteria - metabolism Bifidobacterium Cecum Community structure Deoxyribonucleic acid Diabetes mellitus Digestive system DNA DNA sequencing Dysbacteriosis Dysbiosis - etiology Dysbiosis - metabolism Dysbiosis - pathology Feces - microbiology Gastrointestinal Microbiome Gastrointestinal tract Gene expression Gene Expression Regulation Genera Humanities and Social Sciences Intestinal microflora Intestine Lipid metabolism Listeria Metabolic disorders Metabolic syndrome Metagenomics - methods Mice Mice, Inbred C57BL Mice, Knockout Microbiomes Microbiota multidisciplinary Phenotypes RNA, Ribosomal, 16S - analysis RNA, Ribosomal, 16S - genetics Science Science (multidisciplinary) Serotonin Serotonin Plasma Membrane Transport Proteins - physiology Serotonin transporter Species
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