New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?
BACKGROUND Diabetes mellitus (DM) is a risk factor for renal failure and possibly for renal cell carcinoma (RCC). Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or re...
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| Veröffentlicht in: | Annals of Transplantation 2019-02, Vol.24, p.62-69 |
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| container_title | Annals of Transplantation |
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| creator | Nie, Haibo Wang, Wei Zhao, Yongbin Zhang, Xiaoming Xiao, Yuansong Zeng, Qinsong Zhang, Changzhen Zhang, Lei |
| description | BACKGROUND Diabetes mellitus (DM) is a risk factor for renal failure and possibly for renal cell carcinoma (RCC). Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or renal failure. MATERIAL AND METHODS Data of 96,699 discharged patients with and without NODAT were extracted from the 2005-2014 Nationwide Inpatient Sample (NIS) database, after excluding patients with DM diagnosed at least 1 year prior to renal transplantation. Main outcomes were RCC diagnosis less than 1-year post-transplantation, RCC stage, and renal failure. Univariate and multivariate regression analyses were performed to identify demographic and clinical factors associated with post-transplantation RCC or renal failure. RESULTS Significant differences were found in age and race between patients with and without NODAT (both P |
| doi_str_mv | 10.12659/AOT.909099 |
| format | Article |
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Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or renal failure. MATERIAL AND METHODS Data of 96,699 discharged patients with and without NODAT were extracted from the 2005-2014 Nationwide Inpatient Sample (NIS) database, after excluding patients with DM diagnosed at least 1 year prior to renal transplantation. Main outcomes were RCC diagnosis less than 1-year post-transplantation, RCC stage, and renal failure. Univariate and multivariate regression analyses were performed to identify demographic and clinical factors associated with post-transplantation RCC or renal failure. RESULTS Significant differences were found in age and race between patients with and without NODAT (both P<0.001). The renal failure rate was 0.8% (n=1) in NODAT patients and 0.3% (n=314) in those without NODAT. Older age (OR, 1.030; 95% CI: 1.023 to 1.036), male (OR, 1.872; 95% CI: 1.409 to 2.486), Black (OR, 2.199; 95% CI: 1.574 to 3.071) and hospitalization in urban teaching hospitals were associated with increased risk of RCC. CONCLUSIONS Analysis of over 90,000 NIS hospitalizations with diagnosis-coded kidney transplantation suggested that NODAT may not be an independent risk factor for RCC and renal failure.</description><identifier>ISSN: 2329-0358</identifier><identifier>ISSN: 1425-9524</identifier><identifier>EISSN: 2329-0358</identifier><identifier>DOI: 10.12659/AOT.909099</identifier><identifier>PMID: 30713333</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Original Paper</subject><ispartof>Annals of Transplantation, 2019-02, Vol.24, p.62-69</ispartof><rights>Ann Transplant, 2019 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-37e677a514ec219025ad2fe301381d857342278bbd7fd6c885bdf384bc7bf77b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373244/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373244/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30713333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nie, Haibo</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zhao, Yongbin</creatorcontrib><creatorcontrib>Zhang, Xiaoming</creatorcontrib><creatorcontrib>Xiao, Yuansong</creatorcontrib><creatorcontrib>Zeng, Qinsong</creatorcontrib><creatorcontrib>Zhang, Changzhen</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><title>New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?</title><title>Annals of Transplantation</title><addtitle>Ann Transplant</addtitle><description>BACKGROUND Diabetes mellitus (DM) is a risk factor for renal failure and possibly for renal cell carcinoma (RCC). Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or renal failure. MATERIAL AND METHODS Data of 96,699 discharged patients with and without NODAT were extracted from the 2005-2014 Nationwide Inpatient Sample (NIS) database, after excluding patients with DM diagnosed at least 1 year prior to renal transplantation. Main outcomes were RCC diagnosis less than 1-year post-transplantation, RCC stage, and renal failure. Univariate and multivariate regression analyses were performed to identify demographic and clinical factors associated with post-transplantation RCC or renal failure. RESULTS Significant differences were found in age and race between patients with and without NODAT (both P<0.001). The renal failure rate was 0.8% (n=1) in NODAT patients and 0.3% (n=314) in those without NODAT. Older age (OR, 1.030; 95% CI: 1.023 to 1.036), male (OR, 1.872; 95% CI: 1.409 to 2.486), Black (OR, 2.199; 95% CI: 1.574 to 3.071) and hospitalization in urban teaching hospitals were associated with increased risk of RCC. CONCLUSIONS Analysis of over 90,000 NIS hospitalizations with diagnosis-coded kidney transplantation suggested that NODAT may not be an independent risk factor for RCC and renal failure.</description><subject>Original Paper</subject><issn>2329-0358</issn><issn>1425-9524</issn><issn>2329-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVUd1LwzAQD6I4mXvyXfKoSGc-2qX1QSmb08FYYdTnkKSJBrt2JNnE_97i3Jh3cHfcx--4-wFwhdEQk1GS3edFOcxQp9kJuCCUZBGiSXp6FPfAwHsrUUxIhnGSnIMeRQzTTi7AdqG_oqLxOsCJFVIH7WFugnZwqRtRw9KJxq9r0QQRbNvAm0UxycvbBzjzcBaggEvrP-FUqNA6aNr92FjXnRFO2aZdCXjIT4WtN04_XYIzI2qvB3--D96mz-X4NZoXL7NxPo8UTXGIKNMjxkSCY60IzhBJREWMpgh35SpNGO2OYqmUFTPVSKVpIitD01gqJg1jkvbB4w53vZErXSndBCdqvnZ2Jdw3b4Xl_yuN_eDv7ZaPKKMkjjuAux2Acq33TpvDLEb8lwHeMcB3DHTd18frDr37f9MfSf-Azg</recordid><startdate>20190204</startdate><enddate>20190204</enddate><creator>Nie, Haibo</creator><creator>Wang, Wei</creator><creator>Zhao, Yongbin</creator><creator>Zhang, Xiaoming</creator><creator>Xiao, Yuansong</creator><creator>Zeng, Qinsong</creator><creator>Zhang, Changzhen</creator><creator>Zhang, Lei</creator><general>International Scientific Literature, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20190204</creationdate><title>New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?</title><author>Nie, Haibo ; Wang, Wei ; Zhao, Yongbin ; Zhang, Xiaoming ; Xiao, Yuansong ; Zeng, Qinsong ; Zhang, Changzhen ; Zhang, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-37e677a514ec219025ad2fe301381d857342278bbd7fd6c885bdf384bc7bf77b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Original Paper</topic><toplevel>online_resources</toplevel><creatorcontrib>Nie, Haibo</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Zhao, Yongbin</creatorcontrib><creatorcontrib>Zhang, Xiaoming</creatorcontrib><creatorcontrib>Xiao, Yuansong</creatorcontrib><creatorcontrib>Zeng, Qinsong</creatorcontrib><creatorcontrib>Zhang, Changzhen</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nie, Haibo</au><au>Wang, Wei</au><au>Zhao, Yongbin</au><au>Zhang, Xiaoming</au><au>Xiao, Yuansong</au><au>Zeng, Qinsong</au><au>Zhang, Changzhen</au><au>Zhang, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?</atitle><jtitle>Annals of Transplantation</jtitle><addtitle>Ann Transplant</addtitle><date>2019-02-04</date><risdate>2019</risdate><volume>24</volume><spage>62</spage><epage>69</epage><pages>62-69</pages><issn>2329-0358</issn><issn>1425-9524</issn><eissn>2329-0358</eissn><abstract>BACKGROUND Diabetes mellitus (DM) is a risk factor for renal failure and possibly for renal cell carcinoma (RCC). Post-transplantation DM occurs frequently after solid organ transplantation. We investigated whether new-onset diabetes after renal transplantation (NODAT) is a risk factor for RCC or renal failure. MATERIAL AND METHODS Data of 96,699 discharged patients with and without NODAT were extracted from the 2005-2014 Nationwide Inpatient Sample (NIS) database, after excluding patients with DM diagnosed at least 1 year prior to renal transplantation. Main outcomes were RCC diagnosis less than 1-year post-transplantation, RCC stage, and renal failure. Univariate and multivariate regression analyses were performed to identify demographic and clinical factors associated with post-transplantation RCC or renal failure. RESULTS Significant differences were found in age and race between patients with and without NODAT (both P<0.001). The renal failure rate was 0.8% (n=1) in NODAT patients and 0.3% (n=314) in those without NODAT. Older age (OR, 1.030; 95% CI: 1.023 to 1.036), male (OR, 1.872; 95% CI: 1.409 to 2.486), Black (OR, 2.199; 95% CI: 1.574 to 3.071) and hospitalization in urban teaching hospitals were associated with increased risk of RCC. CONCLUSIONS Analysis of over 90,000 NIS hospitalizations with diagnosis-coded kidney transplantation suggested that NODAT may not be an independent risk factor for RCC and renal failure.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>30713333</pmid><doi>10.12659/AOT.909099</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Original Paper |
| title | New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure? |
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