Pulse exposure of haematopoietic grafts to prostaglandin E2 in vitro facilitates engraftment and recovery

The aim of this study was to evaluate the effects of prostaglandin E(2) (PGE(2) ) on haematopoietic stem cell (HSC) function and determine its mechanism of action. HSC were exposed to PGE(2) for 2 h and effects on their homing, engraftment and self-renewal evaluated in vivo. Effects of PGE(2) on HSC...

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Veröffentlicht in:	Cell proliferation 2011-04, Vol.44 Suppl 1 (Suppl 1), p.22-29
Hauptverfasser:	Pelus, L M, Hoggatt, J, Singh, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Cycle - drug effects Cell Movement - drug effects Chemokine CXCL12 - metabolism Dinoprostone - administration & dosage Dinoprostone - pharmacology Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Humans Mice Mice, Inbred C57BL Original Receptors, CXCR4 - metabolism
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