Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1...

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Veröffentlicht in:	Cell reports (Cambridge) 2018-11, Vol.25 (9), p.2417-2430.e5
Hauptverfasser:	Lee, SungKyoung, Cieply, Benjamin, Yang, Yueqin, Peart, Natoya, Glaser, Carl, Chan, Patricia, Carstens, Russ P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alopecia - pathology Alternative Splicing - genetics Animals Animals, Newborn Cell Membrane Permeability CRISPR-Cas Systems - genetics epidermis Epithelial Cells - metabolism Exons - genetics Inflammation - pathology Keratinocytes - metabolism Mesoderm - metabolism Mice, Knockout Myosin Light Chains - metabolism p21-Activated Kinases - metabolism Phosphorylation Protein Isoforms - genetics Protein Isoforms - metabolism Rho Guanine Nucleotide Exchange Factors - genetics Rho Guanine Nucleotide Exchange Factors - metabolism rhoA GTP-Binding Protein - metabolism RNA-Binding Proteins - metabolism Tight Junctions - metabolism
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