β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides

Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting low-energy structures and global structural ensembles of individual CPs is critical for the design of bioactive molecules, but these are challenging t...

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Veröffentlicht in:	Biophysical journal 2019-02, Vol.116 (3), p.433-444
Hauptverfasser:	Cummings, Ashleigh E., Miao, Jiayuan, Slough, Diana P., McHugh, Sean M., Kritzer, Joshua A., Lin, Yu-Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Models, Molecular Oligopeptides - chemistry Peptides, Cyclic - chemistry Protein Conformation Protein Stability
Online-Zugang:	Volltext
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