Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells

Abstact Decidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of receptor activator for nuclear factor-κ B ligand (RANKL) on decidual stromal cells (DSCs),...

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Veröffentlicht in:	Cell death & disease 2019-02, Vol.10 (2), p.113, Article 113
Hauptverfasser:	Chang, Rui-Qi, Shao, Jun, Meng, Yu-Han, Wang, Jian, Li, Da-Jin, Li, Ming-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 13/51 14 14/34 38 631/250/2152/569 692/699/2732/2730 Abortion, Habitual - immunology Abortion, Habitual - metabolism Abortion, Habitual - pathology Adult Animals Antibodies Biochemistry Biomedical and Life Sciences Cell activation Cell Biology Cell Culture Cell Plasticity - physiology Coculture Techniques Decidua Decidua - cytology Decidua - immunology Decidua - metabolism Decidua - pathology Female Fetuses Foxp3 protein Humans Immunological tolerance Immunology Integrins Intercellular adhesion molecule 1 Life Sciences Lymphocytes B Lymphocytes T Male Maternal-Fetal Exchange Mice Mice, Knockout Miscarriage NF-κB protein Peripheral blood Phenotype Polarization Pregnancy RANK Ligand - immunology RANK Ligand - metabolism Receptor Activator of Nuclear Factor-kappa B - metabolism Receptors, Antigen, T-Cell, gamma-delta - biosynthesis Receptors, Antigen, T-Cell, gamma-delta - immunology Stromal cells T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - pathology TRANCE protein Transfection Transforming growth factor Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Uterus Vascular cell adhesion molecule 1
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