Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a single-domain antibody fragment (“nanobody”) discovered using a synt...

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Veröffentlicht in:	Cell 2019-01, Vol.176 (3), p.479-490.e12
Hauptverfasser:	Wingler, Laura M., McMahon, Conor, Staus, Dean P., Lefkowitz, Robert J., Kruse, Andrew C.
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Angiotensin II Angiotensin II Type 1 Receptor Blockers - metabolism angiotensin receptor antibodies Arrestins - metabolism BASIC BIOLOGICAL SCIENCES beta-Arrestins - metabolism biased agonism crystal structure G protein-coupled receptor G-protein coupled receptors GPCR HEK293 Cells Humans Immunoglobulin Fragments - pharmacology nanobody Protein Conformation Proto-Oncogene Proteins Receptor, Angiotensin, Type 1 - metabolism Receptors, G-Protein-Coupled - metabolism renal function Signal Transduction - drug effects Single-Domain Antibodies - metabolism Single-Domain Antibodies - pharmacology single-domain antibody yeast display
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