Polydatin Increases Radiosensitivity by Inducing Apoptosis of Stem Cells in Colorectal Cancer

This study aimed to investigate the radiosensitizing effect of polydatin (PD) on colorectal cancer (CRC) and its underlying mechanism. The C57BL/6 mouse model of CRC was induced by treatment with azoxymethane (AOM)/dextran sodium sulfate (DSS) and then divided into four groups: control, PD alone, IR...

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Veröffentlicht in:	International journal of biological sciences 2019, Vol.15 (2), p.430-440
Hauptverfasser:	Chen, Qiu, Zeng, Ya-Nan, Zhang, Ke, Zhao, Ying, Wu, Yong-You, Li, Gen, Cheng, Hui-Ying, Zhang, Meng, Lai, Feng, Wang, Jin-Bing, Cui, Feng-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Azoxymethane Bone morphogenetic proteins Cancer Cancer therapies Caspase Caspase-3 Cell proliferation Cell Proliferation - drug effects Cell Survival Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Combined treatment Cytotoxicity Dextran G protein-coupled receptors Glucosides - pharmacology HCT116 Cells Humans Immunohistochemistry Infrared radiation Leucine Male Mice Mice, Inbred C57BL Proteins Radiation Radiation therapy Radiosensitivity Research Paper Signal transduction Sodium Sodium sulfate Stem cell transplantation Stem cells Stilbenes - pharmacology Tumor cells Tumors Xenografts Xenotransplantation
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