Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum

CT screening can reduce death from lung cancer. We sought to improve the diagnostic accuracy of lung cancer screening using ultrasensitive methods and a lung cancer-specific gene panel to detect DNA methylation in sputum and plasma. This is a case-control study of subjects with suspicious nodules on...

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Veröffentlicht in:	Clinical cancer research 2017-04, Vol.23 (8), p.1998-2005
Hauptverfasser:	Hulbert, Alicia, Jusue-Torres, Ignacio, Stark, Alejandro, Chen, Chen, Rodgers, Kristen, Lee, Beverly, Griffin, Candace, Yang, Andrew, Huang, Peng, Wrangle, John, Belinsky, Steven A, Wang, Tza-Huei, Yang, Stephen C, Baylin, Stephen B, Brock, Malcolm V, Herman, James G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Area Under Curve Beads Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cancer Cancer screening Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Case-Control Studies Computed tomography Confidence intervals Deoxyribonucleic acid Diagnostic systems DNA DNA - analysis DNA methylation DNA Methylation - genetics Early Detection of Cancer - methods Experimental design Female Gene Expression Profiling - methods Genes Humans Lung cancer Lung Neoplasms - blood Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Medical screening Middle Aged Nodules Plasma Prediction models Promoter Regions, Genetic - genetics Real-Time Polymerase Chain Reaction ROC Curve Sensitivity Sensitivity and Specificity Sputum Sputum - chemistry Transcriptome
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