Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats
Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabetic rats. Wistar...
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| Veröffentlicht in: | In vivo (Athens) 2018-11, Vol.32 (6), p.1433-1441 |
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| creator | Nakos, Ioannis Kadoglou, Nikolaos P E Gkeka, Paraskevi Tzallas, Alexandros T Giannakeas, Nikolaos Tsalikakis, Dimitrios G Katsimpoulas, Michalis Mantziaras, Georgios Kostomitsopoulos, Nikolaos Liapis, Christos D Kakisis, John |
| description | Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabetic rats.
Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p |
| doi_str_mv | 10.21873/invivo.11396 |
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Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p<0.001) and R-wave amplitude (p<0.05). Frequency-domain spectral variables were also analyzed. The SD group had a significantly lower absolute high-frequency component (p<0.05) and higher normalized low-frequency component, as well as low-frequency power divided by the high-frequency power ratio when compared to the SC and EC groups (p<0.05). All these diabetes-related adverse changes in heart rate variability parameters were significantly reversed by exercise training (p<0.05). Overall, our study shows that early initiation of systemic exercise training prevents the development of cardiac autonomic neuropathy in rats with type 1 diabetes mellitus, by favorable change in the balance between parasympathetic and sympathetic activity.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>DOI: 10.21873/invivo.11396</identifier><identifier>PMID: 30348698</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Animals ; Autonomic Nervous System - metabolism ; Autonomic Nervous System - physiopathology ; Autonomic Pathways ; Biomarkers ; Diabetes Mellitus, Experimental - metabolism ; Diabetes Mellitus, Experimental - physiopathology ; Electrocardiography ; Heart - innervation ; Heart - physiopathology ; Heart Rate ; Male ; Physical Conditioning, Animal ; Rats</subject><ispartof>In vivo (Athens), 2018-11, Vol.32 (6), p.1433-1441</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright 2018, International Institute of Anticancer Research 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-3ac139e5257276b55b12c270954d564df4ec89fc0520af32ea75d84852e3f8253</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365738/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365738/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30348698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakos, Ioannis</creatorcontrib><creatorcontrib>Kadoglou, Nikolaos P E</creatorcontrib><creatorcontrib>Gkeka, Paraskevi</creatorcontrib><creatorcontrib>Tzallas, Alexandros T</creatorcontrib><creatorcontrib>Giannakeas, Nikolaos</creatorcontrib><creatorcontrib>Tsalikakis, Dimitrios G</creatorcontrib><creatorcontrib>Katsimpoulas, Michalis</creatorcontrib><creatorcontrib>Mantziaras, Georgios</creatorcontrib><creatorcontrib>Kostomitsopoulos, Nikolaos</creatorcontrib><creatorcontrib>Liapis, Christos D</creatorcontrib><creatorcontrib>Kakisis, John</creatorcontrib><title>Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabetic rats.
Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p<0.001) and R-wave amplitude (p<0.05). Frequency-domain spectral variables were also analyzed. The SD group had a significantly lower absolute high-frequency component (p<0.05) and higher normalized low-frequency component, as well as low-frequency power divided by the high-frequency power ratio when compared to the SC and EC groups (p<0.05). All these diabetes-related adverse changes in heart rate variability parameters were significantly reversed by exercise training (p<0.05). Overall, our study shows that early initiation of systemic exercise training prevents the development of cardiac autonomic neuropathy in rats with type 1 diabetes mellitus, by favorable change in the balance between parasympathetic and sympathetic activity.</description><subject>Animals</subject><subject>Autonomic Nervous System - metabolism</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Autonomic Pathways</subject><subject>Biomarkers</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Electrocardiography</subject><subject>Heart - innervation</subject><subject>Heart - physiopathology</subject><subject>Heart Rate</subject><subject>Male</subject><subject>Physical Conditioning, Animal</subject><subject>Rats</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLJDEURoM4aKuzdCtZuinNo1JJbYSmu32AMDD0gKsJ6dQtjVQlbZJq7H8_pa3irAI3h-9-3IPQKSUXjCrJL53fuE24oJTX1R6aUFnTQoqy3kcTwoQqlKAPh-gopWdCKkkIO0CHnPBSVbWaoL-LV4jWJcDLaJx3_hFPcwY_mAwJ5yfAc9hAF9Y9-IxDi2cmNs5YPB1y8KF3Fs-3qR28zS547DyeO7OCPM5_m5xO0I_WdAl-frzH6M_1Yjm7Le5_3dzNpveF5Urmghs71gfBhGSyWgmxoswySWpRNqIqm7YEq-rWEsGIaTkDI0WjSiUY8FYxwY_R1S53Pax6aOxYNppOr6PrTdzqYJz-_8e7J_0YNrrilZBcjQHnHwExvAyQsu5dstB1xkMYkmbjXdlbIzqixQ61MaQUof1aQ4l-d6J3TvS7k5E_-97ti_6UwP8B41GKnQ</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Nakos, Ioannis</creator><creator>Kadoglou, Nikolaos P E</creator><creator>Gkeka, Paraskevi</creator><creator>Tzallas, Alexandros T</creator><creator>Giannakeas, Nikolaos</creator><creator>Tsalikakis, Dimitrios G</creator><creator>Katsimpoulas, Michalis</creator><creator>Mantziaras, Georgios</creator><creator>Kostomitsopoulos, Nikolaos</creator><creator>Liapis, Christos D</creator><creator>Kakisis, John</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats</title><author>Nakos, Ioannis ; Kadoglou, Nikolaos P E ; Gkeka, Paraskevi ; Tzallas, Alexandros T ; Giannakeas, Nikolaos ; Tsalikakis, Dimitrios G ; Katsimpoulas, Michalis ; Mantziaras, Georgios ; Kostomitsopoulos, Nikolaos ; Liapis, Christos D ; Kakisis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-3ac139e5257276b55b12c270954d564df4ec89fc0520af32ea75d84852e3f8253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - metabolism</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Autonomic Pathways</topic><topic>Biomarkers</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Electrocardiography</topic><topic>Heart - innervation</topic><topic>Heart - physiopathology</topic><topic>Heart Rate</topic><topic>Male</topic><topic>Physical Conditioning, Animal</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakos, Ioannis</creatorcontrib><creatorcontrib>Kadoglou, Nikolaos P E</creatorcontrib><creatorcontrib>Gkeka, Paraskevi</creatorcontrib><creatorcontrib>Tzallas, Alexandros T</creatorcontrib><creatorcontrib>Giannakeas, Nikolaos</creatorcontrib><creatorcontrib>Tsalikakis, Dimitrios G</creatorcontrib><creatorcontrib>Katsimpoulas, Michalis</creatorcontrib><creatorcontrib>Mantziaras, Georgios</creatorcontrib><creatorcontrib>Kostomitsopoulos, Nikolaos</creatorcontrib><creatorcontrib>Liapis, Christos D</creatorcontrib><creatorcontrib>Kakisis, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakos, Ioannis</au><au>Kadoglou, Nikolaos P E</au><au>Gkeka, Paraskevi</au><au>Tzallas, Alexandros T</au><au>Giannakeas, Nikolaos</au><au>Tsalikakis, Dimitrios G</au><au>Katsimpoulas, Michalis</au><au>Mantziaras, Georgios</au><au>Kostomitsopoulos, Nikolaos</au><au>Liapis, Christos D</au><au>Kakisis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>32</volume><issue>6</issue><spage>1433</spage><epage>1441</epage><pages>1433-1441</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Exercise training usually complements pharmacological therapy of type 1 diabetes mellitus, however, little is known about its impact on cardiac autonomic neuropathy. Our aim was to evaluate the impact of exercise on electrocardiographic parameters and heart rate variability in diabetic rats.
Wistar rats were randomly assigned to four groups (n=12): Sedentary control (SC), sedentary diabetic (SD), exercise control (EC), and exercise diabetic (ED). Diabetes was induced by a single intraperitoneal injection of streptozotocin (45 mg/kg). Exercise groups underwent 8 weeks of training on a treadmill. At the end of the study, echocardiography was performed and continuous electrocardiographic recording was obtained by intra-abdominally implanted telemetric devices. Diabetes induction significantly reduced the heart rate and increased the blood glucose level (p<0.001) and R-wave amplitude (p<0.05). Frequency-domain spectral variables were also analyzed. The SD group had a significantly lower absolute high-frequency component (p<0.05) and higher normalized low-frequency component, as well as low-frequency power divided by the high-frequency power ratio when compared to the SC and EC groups (p<0.05). All these diabetes-related adverse changes in heart rate variability parameters were significantly reversed by exercise training (p<0.05). Overall, our study shows that early initiation of systemic exercise training prevents the development of cardiac autonomic neuropathy in rats with type 1 diabetes mellitus, by favorable change in the balance between parasympathetic and sympathetic activity.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>30348698</pmid><doi>10.21873/invivo.11396</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autonomic Nervous System - metabolism Autonomic Nervous System - physiopathology Autonomic Pathways Biomarkers Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - physiopathology Electrocardiography Heart - innervation Heart - physiopathology Heart Rate Male Physical Conditioning, Animal Rats |
| title | Exercise Training Attenuates the Development of Cardiac Autonomic Dysfunction in Diabetic Rats |
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