Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer
Calcium phosphate cement (CPC) is used to fill bone voids in dental, orthopedic, and craniofacial applications. This study evaluated CPC marker as an injectable non-metallic fiducial marker. Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before...
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| Veröffentlicht in: | In vivo (Athens) 2018-11, Vol.32 (6), p.1609-1615 |
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| creator | Ogino, Ichiro Kitagawa, Masakazu Watanabe, Shigenobu Yoshida, Hiroshi Hata, Masaharu |
| description | Calcium phosphate cement (CPC) is used to fill bone voids in dental, orthopedic, and craniofacial applications. This study evaluated CPC marker as an injectable non-metallic fiducial marker.
Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were treated with external-beam radiotherapy (EBRT) and high-dose rate brachytherapy (BT). We investigated marker visibility on cone-beam CT (CBCT), T2-weighted MRI, and interfraction of the marker motion for cervical cancer patients.
Of a total of 22 visible CPC markers at TPCT, 17 CPC markers were visible on the first CBCT. Excluding one patient, all markers were visible on CBCT during EBRT. Of 16 visible CPC markers on CBCT, 13 CPC markers were visible on the magnetic resonance imaging (MRI) obtained before BT. For CPC marker centroid movement, the mean-of-means/systematic variation/random variation were 0.2/0.4/1.4, -1.6/5.1/4.1, and -3.4/2.1/2.8 mm for the left-right, dorsal-ventral, and cranial-caudal directions, respectively.
This is the first report of a CPC marker injected into tumors of the cervix. It can be visualized on CBCT and MRI with reductions in marker loss and artifacts. |
| doi_str_mv | 10.21873/invivo.11421 |
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Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were treated with external-beam radiotherapy (EBRT) and high-dose rate brachytherapy (BT). We investigated marker visibility on cone-beam CT (CBCT), T2-weighted MRI, and interfraction of the marker motion for cervical cancer patients.
Of a total of 22 visible CPC markers at TPCT, 17 CPC markers were visible on the first CBCT. Excluding one patient, all markers were visible on CBCT during EBRT. Of 16 visible CPC markers on CBCT, 13 CPC markers were visible on the magnetic resonance imaging (MRI) obtained before BT. For CPC marker centroid movement, the mean-of-means/systematic variation/random variation were 0.2/0.4/1.4, -1.6/5.1/4.1, and -3.4/2.1/2.8 mm for the left-right, dorsal-ventral, and cranial-caudal directions, respectively.
This is the first report of a CPC marker injected into tumors of the cervix. It can be visualized on CBCT and MRI with reductions in marker loss and artifacts.</description><identifier>ISSN: 0258-851X</identifier><identifier>EISSN: 1791-7549</identifier><identifier>DOI: 10.21873/invivo.11421</identifier><identifier>PMID: 30348723</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bone Cements - therapeutic use ; Calcium Phosphates - therapeutic use ; Cone-Beam Computed Tomography - methods ; Female ; Fiducial Markers ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Uterine Cervical Neoplasms - diagnostic imaging ; Uterine Cervical Neoplasms - pathology</subject><ispartof>In vivo (Athens), 2018-11, Vol.32 (6), p.1609-1615</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright 2018, International Institute of Anticancer Research 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-62d5582fba412d780b6e34153f28f030f80cd006033d7e7ef29d34902f6ba3ea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365722/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365722/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30348723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogino, Ichiro</creatorcontrib><creatorcontrib>Kitagawa, Masakazu</creatorcontrib><creatorcontrib>Watanabe, Shigenobu</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><title>Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer</title><title>In vivo (Athens)</title><addtitle>In Vivo</addtitle><description>Calcium phosphate cement (CPC) is used to fill bone voids in dental, orthopedic, and craniofacial applications. This study evaluated CPC marker as an injectable non-metallic fiducial marker.
Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were treated with external-beam radiotherapy (EBRT) and high-dose rate brachytherapy (BT). We investigated marker visibility on cone-beam CT (CBCT), T2-weighted MRI, and interfraction of the marker motion for cervical cancer patients.
Of a total of 22 visible CPC markers at TPCT, 17 CPC markers were visible on the first CBCT. Excluding one patient, all markers were visible on CBCT during EBRT. Of 16 visible CPC markers on CBCT, 13 CPC markers were visible on the magnetic resonance imaging (MRI) obtained before BT. For CPC marker centroid movement, the mean-of-means/systematic variation/random variation were 0.2/0.4/1.4, -1.6/5.1/4.1, and -3.4/2.1/2.8 mm for the left-right, dorsal-ventral, and cranial-caudal directions, respectively.
This is the first report of a CPC marker injected into tumors of the cervix. It can be visualized on CBCT and MRI with reductions in marker loss and artifacts.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Cements - therapeutic use</subject><subject>Calcium Phosphates - therapeutic use</subject><subject>Cone-Beam Computed Tomography - methods</subject><subject>Female</subject><subject>Fiducial Markers</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Middle Aged</subject><subject>Uterine Cervical Neoplasms - diagnostic imaging</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9LwzAUx4Mobk6PXiVHL5350TbZRZDidKC4g4K3kKaJy2ybmbQF_3vDNoeeHu-9D9_35X0BuMRoSjBn9Ma2gx3cFOOU4CMwxmyGE5als2MwRiTjCc_w-wichbBGKGcIkVMwooimnBE6BstC1sr2DVyuXNisZKdhoRvddnApQ2wW7VqrzroWygAlnNuqV1bW8Fn6T-2hMxH3g1VxVMhWaX8OToysg77Y1wl4m9-_Fo_J08vDorh7SlSa0S7JSZVlnJhSpphUjKMy1zTFGTWEG0SR4UhV0TCitGKaaUNmFU1niJi8lFRLOgG3O91NXza6UtGyl7XYeNtI_y2ctOL_prUr8eEGkdM8Y4REgeu9gHdfvQ6daGxQuq5lq10fBImfJJGjOKLJDlXeheC1OZzBSGxTELsUxDaFyF_99Xagf99OfwD85IRg</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Ogino, Ichiro</creator><creator>Kitagawa, Masakazu</creator><creator>Watanabe, Shigenobu</creator><creator>Yoshida, Hiroshi</creator><creator>Hata, Masaharu</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer</title><author>Ogino, Ichiro ; Kitagawa, Masakazu ; Watanabe, Shigenobu ; Yoshida, Hiroshi ; Hata, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-62d5582fba412d780b6e34153f28f030f80cd006033d7e7ef29d34902f6ba3ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Cements - therapeutic use</topic><topic>Calcium Phosphates - therapeutic use</topic><topic>Cone-Beam Computed Tomography - methods</topic><topic>Female</topic><topic>Fiducial Markers</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Middle Aged</topic><topic>Uterine Cervical Neoplasms - diagnostic imaging</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogino, Ichiro</creatorcontrib><creatorcontrib>Kitagawa, Masakazu</creatorcontrib><creatorcontrib>Watanabe, Shigenobu</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogino, Ichiro</au><au>Kitagawa, Masakazu</au><au>Watanabe, Shigenobu</au><au>Yoshida, Hiroshi</au><au>Hata, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>32</volume><issue>6</issue><spage>1609</spage><epage>1615</epage><pages>1609-1615</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>Calcium phosphate cement (CPC) is used to fill bone voids in dental, orthopedic, and craniofacial applications. This study evaluated CPC marker as an injectable non-metallic fiducial marker.
Six patients received 3-5 injections of CPC paste placed at a depth of 10 mm into tumors of the cervix before treatment planning CT (TPCT). Patients were treated with external-beam radiotherapy (EBRT) and high-dose rate brachytherapy (BT). We investigated marker visibility on cone-beam CT (CBCT), T2-weighted MRI, and interfraction of the marker motion for cervical cancer patients.
Of a total of 22 visible CPC markers at TPCT, 17 CPC markers were visible on the first CBCT. Excluding one patient, all markers were visible on CBCT during EBRT. Of 16 visible CPC markers on CBCT, 13 CPC markers were visible on the magnetic resonance imaging (MRI) obtained before BT. For CPC marker centroid movement, the mean-of-means/systematic variation/random variation were 0.2/0.4/1.4, -1.6/5.1/4.1, and -3.4/2.1/2.8 mm for the left-right, dorsal-ventral, and cranial-caudal directions, respectively.
This is the first report of a CPC marker injected into tumors of the cervix. It can be visualized on CBCT and MRI with reductions in marker loss and artifacts.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>30348723</pmid><doi>10.21873/invivo.11421</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Bone Cements - therapeutic use Calcium Phosphates - therapeutic use Cone-Beam Computed Tomography - methods Female Fiducial Markers Humans Magnetic Resonance Imaging Middle Aged Uterine Cervical Neoplasms - diagnostic imaging Uterine Cervical Neoplasms - pathology |
| title | Calcium Phosphate Cement Paste Injection as a Fiducial Marker of Cervical Cancer |
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