Robustness by intrinsically disordered C-termini and translational readthrough

Abstract During protein synthesis genetic instructions are passed from DNA via mRNA to the ribosome to assemble a protein chain. Occasionally, stop codons in the mRNA are bypassed and translation continues into the untranslated region (3′-UTR). This process, called translational readthrough (TR), yi...

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Veröffentlicht in:	Nucleic acids research 2018-11, Vol.46 (19), p.10184-10194
Hauptverfasser:	Kleppe, April Snofrid, Bornberg-Bauer, Erich
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Codon - chemistry Codon - metabolism Codon, Terminator Computational Biology DNA Mutational Analysis Frameshift Mutation - genetics Frameshifting, Ribosomal - physiology Molecular Biology Nucleic Acid Conformation Open Reading Frames - genetics Peptide Chain Termination, Translational - physiology Protein Biosynthesis - physiology Ribosomal Proteins - metabolism Ribosomes - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism
Online-Zugang:	Volltext
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