Network-based integrated analysis of omics data reveal novel players of TGF-β1-induced EMT in human peritoneal mesothelial cells

Long-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) of mesothelial cells is an important mechanism involved in peritoneal fibrosis, and TGF-β1 is considered central in this process. However, targeting currently known TGF-β1...

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Veröffentlicht in:	Scientific reports 2019-02, Vol.9 (1), p.1497-1497, Article 1497
Hauptverfasser:	Han, Soo Min, Ryu, Hye-Myung, Suh, Jinjoo, Lee, Kong-Joo, Choi, Soon-Youn, Choi, Sangdun, Kim, Yong-Lim, Huh, Joo Young, Ha, Hunjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/95 38/39 38/61 38/77 38/89 631/114/2401 631/337/2019 692/4022/1950/1724 82/1 Data processing Dialysis E-cadherin Extracellular matrix Fibronectin Fibrosis Humanities and Social Sciences Mesenchyme multidisciplinary Oxidative stress Peritoneal dialysis Peritoneum Proteomics Science Science (multidisciplinary) Therapeutic applications Transforming growth factor-b1 Zonula occludens-1 protein
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