An intrinsic S/G2 checkpoint enforced by ATR

An additional cell cycle checkpointCell division is controlled by checkpoints that regulate the temporal order of the cell cycle phases, including the G1/S, G2/M, and metaphase/anaphase transitions. Yet there are no known control mechanisms for a fourth fundamental transition—the S/G2 transition. Sa...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-08, Vol.361 (6404), p.806-810
Hauptverfasser:	Saldivar, Joshua C, Hamperl Stephan, Bocek, Michael J, Chung, Mingyu, Bass, Thomas E, Cisneros-Soberanis Fernanda, Samejima Kumiko, Xie Linfeng, Paulson, James R, Earnshaw, William C, Cortez, David, Meyer, Tobias, Cimprich, Karlene A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase Ataxia Ataxia telangiectasia Cell cycle Cell division Cyclin-dependent kinase Cyclin-dependent kinases Deoxyribonucleic acid Deregulation DNA DNA biosynthesis DNA damage Gene duplication Genomes Metaphase Mitosis Phase transitions Phosphorylation Replication S phase Temporal variations Transcription
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