miR‑335 promotes stress granule formation to inhibit apoptosis by targeting ROCK2 in acute ischemic stroke

Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been in...

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Veröffentlicht in:	International journal of molecular medicine 2019-03, Vol.43 (3), p.1452-1466
Hauptverfasser:	Si, Wenwen, Ye, Shanyu, Ren, Zhenxing, Liu, Xin, Wu, Zimei, Li, Yi, Zhou, Jianhong, Zhang, Saixia, Li, Yiwei, Deng, Rudong, Chen, Dongfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Antigens Apoptosis Apoptosis - genetics Brain Brain injuries Brain Ischemia - genetics Brain Ischemia - pathology Care and treatment Cell adhesion & migration Cell cycle Criminal investigation Culture Media, Serum-Free Cytoplasmic Granules - metabolism Death Development and progression Disease Models, Animal Environmental quality Experiments Gene expression Gene Expression Regulation Gene Silencing Genetic aspects Health aspects Infarction, Middle Cerebral Artery - genetics Infarction, Middle Cerebral Artery - pathology Ischemia Kinases Laboratory animals Luciferase Male MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Pathogenesis PC12 Cells Phosphorylation Phosphotransferases Polymerase chain reaction Protein kinases Proteins Rats Rats, Sprague-Dawley Reperfusion rho-Associated Kinases - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stroke Stroke - genetics Stroke - pathology Studies Surgery T cells
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