Ficolin-1 is a promising therapeutic target for autoimmune diseases

An anti-ficolin-1 mAb is effective as therapy for autoimmunity Abstract Previously, we reported that mRNA expression of ficolin-1 (FCN1), a component of the complement lectin pathway, is elevated in peripheral blood mononuclear cells of patients with vasculitis syndrome, and that FCN1-positive cells...

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Veröffentlicht in:	International immunology 2019-02, Vol.31 (1), p.23-32
Hauptverfasser:	Katayama, Michihito, Ota, Kaori, Nagi-Miura, Noriko, Ohno, Naohito, Yabuta, Norikazu, Nojima, Hiroshi, Kumanogoh, Atsushi, Hirano, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoimmune Diseases - drug therapy Autoimmune Diseases - etiology Autoimmune Diseases - metabolism Autoimmune Diseases - pathology Biomarkers Complement System Proteins - immunology Complement System Proteins - metabolism Disease Models, Animal Female Ficolins Humans Lectins - antagonists & inhibitors Lectins - immunology Lectins - metabolism Male Mice Middle Aged Molecular Targeted Therapy Original Research Papers Vasculitis - etiology Vasculitis - metabolism Vasculitis - pathology
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