Rabbit models of human diseases for diagnostics and therapeutics development
This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit mono...
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| Veröffentlicht in: | Developmental and comparative immunology 2019-03, Vol.92, p.99-104 |
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| creator | Mage, Rose G. Esteves, Pedro J. Rader, Christoph |
| description | This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some “humanized” or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other members of the order Lagomorpha are summarized as this knowledge now applies to new therapeutics being developed for several human diseases including Multiple Sclerosis, Type 1 Diabetes and Cancer.
•The laboratory rabbit is a valuable model for studies of human diseases.•The rabbit's genome is more similar to the human genome than are rodents' genomes.•Rabbits produce highly specific high affinity antibodies.•Clinical trials of humanized rabbit monoclonal antibodies are in progress.•New information about engogenous retroviruses may lead to human therapeutics. |
| doi_str_mv | 10.1016/j.dci.2018.10.003 |
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•The laboratory rabbit is a valuable model for studies of human diseases.•The rabbit's genome is more similar to the human genome than are rodents' genomes.•Rabbits produce highly specific high affinity antibodies.•Clinical trials of humanized rabbit monoclonal antibodies are in progress.•New information about engogenous retroviruses may lead to human therapeutics.</description><identifier>ISSN: 0145-305X</identifier><identifier>ISSN: 1879-0089</identifier><identifier>EISSN: 1879-0089</identifier><identifier>DOI: 10.1016/j.dci.2018.10.003</identifier><identifier>PMID: 30339876</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animal models ; Animals ; Cancer ; Cardiovascular disease ; Clinical trials ; Clinical Trials as Topic ; Diabetes mellitus ; Diabetes mellitus (insulin dependent) ; Diabetes Mellitus, Type 1 - immunology ; Diagnostic software ; Diagnostic systems ; diagnostic techniques ; Disease Models, Animal ; Diseases ; Drug development ; Endogenous retroviruses ; human diseases ; Humans ; insulin-dependent diabetes mellitus ; Lagomorpha ; Medical research ; Monoclonal antibodies ; Multiple Sclerosis ; Multiple Sclerosis - immunology ; Neoplasms - immunology ; Ocular diseases ; Oryctolagus cuniculus ; Rabbits ; sclerosis ; Systemic Lupus Erythematosis ; therapeutics ; United States ; United States Food and Drug Administration</subject><ispartof>Developmental and comparative immunology, 2019-03, Vol.92, p.99-104</ispartof><rights>2018</rights><rights>Published by Elsevier Ltd.</rights><rights>Copyright Elsevier Science Ltd. Mar 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-37365ad5ee0e202f622f4434cece6183944b92690328be66416fe88f99ce9f923</citedby><cites>FETCH-LOGICAL-c578t-37365ad5ee0e202f622f4434cece6183944b92690328be66416fe88f99ce9f923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dci.2018.10.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30339876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mage, Rose G.</creatorcontrib><creatorcontrib>Esteves, Pedro J.</creatorcontrib><creatorcontrib>Rader, Christoph</creatorcontrib><title>Rabbit models of human diseases for diagnostics and therapeutics development</title><title>Developmental and comparative immunology</title><addtitle>Dev Comp Immunol</addtitle><description>This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some “humanized” or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other members of the order Lagomorpha are summarized as this knowledge now applies to new therapeutics being developed for several human diseases including Multiple Sclerosis, Type 1 Diabetes and Cancer.
•The laboratory rabbit is a valuable model for studies of human diseases.•The rabbit's genome is more similar to the human genome than are rodents' genomes.•Rabbits produce highly specific high affinity antibodies.•Clinical trials of humanized rabbit monoclonal antibodies are in progress.•New information about engogenous retroviruses may lead to human therapeutics.</description><subject>Animal models</subject><subject>Animals</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (insulin dependent)</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>diagnostic techniques</subject><subject>Disease Models, Animal</subject><subject>Diseases</subject><subject>Drug development</subject><subject>Endogenous retroviruses</subject><subject>human diseases</subject><subject>Humans</subject><subject>insulin-dependent diabetes mellitus</subject><subject>Lagomorpha</subject><subject>Medical research</subject><subject>Monoclonal antibodies</subject><subject>Multiple Sclerosis</subject><subject>Multiple Sclerosis - immunology</subject><subject>Neoplasms - immunology</subject><subject>Ocular diseases</subject><subject>Oryctolagus cuniculus</subject><subject>Rabbits</subject><subject>sclerosis</subject><subject>Systemic Lupus Erythematosis</subject><subject>therapeutics</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>0145-305X</issn><issn>1879-0089</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEURoMoTjv6A9xIgRs31XPzqFSCIAyDL2gQhhHchVRyazpNVaVNqhr896btcVAXYzbh3px8eRxCXlJYU6DyYrf2LqwZUFXqNQB_RFZUtboGUPoxWQEVTc2h-XZGnuW8gzIUhafkjAPnWrVyRTbXtuvCXI3R45Cr2FfbZbRT5UNGmzFXfUylsLdTzHNwubKTr-YtJrvH5VfD4wGHuB9xmp-TJ70dMr64m8_J1w_vb64-1ZsvHz9fXW5q17RqrnnLZWN9gwjIgPWSsV4ILhw6lFRxLUSnmdTAmepQSkFlj0r1WjvUvWb8nLw75e6XbkTvytHJDmafwmjTDxNtMH-vTGFrbuPBSC5F00AJeHMXkOL3BfNsxpAdDoOdMC7ZMMYoyAY0_T9KGW-pFlwX9PU_6C4uaSo_USjFRMs0qELRE-VSzDlhf39vCuao1exM0WqOWo-torXsefXng-93_PZYgLcnoEjEQ8Bksgs4OfQhoZuNj-GB-J83lbJs</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Mage, Rose G.</creator><creator>Esteves, Pedro J.</creator><creator>Rader, Christoph</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Rabbit models of human diseases for diagnostics and therapeutics development</title><author>Mage, Rose G. ; Esteves, Pedro J. ; Rader, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-37365ad5ee0e202f622f4434cece6183944b92690328be66416fe88f99ce9f923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>Clinical Trials as Topic</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (insulin dependent)</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>diagnostic techniques</topic><topic>Disease Models, Animal</topic><topic>Diseases</topic><topic>Drug development</topic><topic>Endogenous retroviruses</topic><topic>human diseases</topic><topic>Humans</topic><topic>insulin-dependent diabetes mellitus</topic><topic>Lagomorpha</topic><topic>Medical research</topic><topic>Monoclonal antibodies</topic><topic>Multiple Sclerosis</topic><topic>Multiple Sclerosis - immunology</topic><topic>Neoplasms - immunology</topic><topic>Ocular diseases</topic><topic>Oryctolagus cuniculus</topic><topic>Rabbits</topic><topic>sclerosis</topic><topic>Systemic Lupus Erythematosis</topic><topic>therapeutics</topic><topic>United States</topic><topic>United States Food and Drug Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mage, Rose G.</creatorcontrib><creatorcontrib>Esteves, Pedro J.</creatorcontrib><creatorcontrib>Rader, Christoph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mage, Rose G.</au><au>Esteves, Pedro J.</au><au>Rader, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rabbit models of human diseases for diagnostics and therapeutics development</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>92</volume><spage>99</spage><epage>104</epage><pages>99-104</pages><issn>0145-305X</issn><issn>1879-0089</issn><eissn>1879-0089</eissn><abstract>This review presents some examples of studies using the European rabbit (Oryctolagus cuniculus) that have led to, and continue to, contribute to advancement of understanding of human diseases as well as therapeutics development. In addition, we tabulate FDA-approved rabbit polyclonal and rabbit monoclonal antibodies (mAbs) that are used for diagnostic applications, as well as an overview of some “humanized” or otherwise altered rabbit mAbs that are in initial phase I, II, or advanced to phase III clinical trials. Information about endogenous retriviruses learned from studies of rabbits and other members of the order Lagomorpha are summarized as this knowledge now applies to new therapeutics being developed for several human diseases including Multiple Sclerosis, Type 1 Diabetes and Cancer.
•The laboratory rabbit is a valuable model for studies of human diseases.•The rabbit's genome is more similar to the human genome than are rodents' genomes.•Rabbits produce highly specific high affinity antibodies.•Clinical trials of humanized rabbit monoclonal antibodies are in progress.•New information about engogenous retroviruses may lead to human therapeutics.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>30339876</pmid><doi>10.1016/j.dci.2018.10.003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal models Animals Cancer Cardiovascular disease Clinical trials Clinical Trials as Topic Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - immunology Diagnostic software Diagnostic systems diagnostic techniques Disease Models, Animal Diseases Drug development Endogenous retroviruses human diseases Humans insulin-dependent diabetes mellitus Lagomorpha Medical research Monoclonal antibodies Multiple Sclerosis Multiple Sclerosis - immunology Neoplasms - immunology Ocular diseases Oryctolagus cuniculus Rabbits sclerosis Systemic Lupus Erythematosis therapeutics United States United States Food and Drug Administration |
| title | Rabbit models of human diseases for diagnostics and therapeutics development |
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