Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD
Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People'...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-03, Vol.17 (3), p.1756-1760 |
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| creator | Liu, Weijing Wang, Tao Sun, Pengfei Zhou, Yanju |
| description | Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P |
| doi_str_mv | 10.3892/etm.2018.7111 |
| format | Article |
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A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL-C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.7111</identifier><identifier>PMID: 30783445</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Angina pectoris ; Atherosclerosis ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Cholesterol ; Coronary heart disease ; Development and progression ; Diabetes ; Enzymes ; Females ; Gene expression ; Genetic aspects ; Health aspects ; Heart ; Heart attack ; Heart attacks ; Heart diseases ; Homocysteine ; Hyperlipidemia ; Hypertension ; Lipids ; Lipoproteins ; Low density lipoproteins ; Medical research ; Metabolism ; Obesity ; Risk factors ; Statistical analysis ; Studies ; Triglycerides</subject><ispartof>Experimental and therapeutic medicine, 2019-03, Vol.17 (3), p.1756-1760</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Liu et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-19b343a8cb3443002ac23faf555fe3073b75998f624e818fbcb26364d584c8d13</citedby><cites>FETCH-LOGICAL-c478t-19b343a8cb3443002ac23faf555fe3073b75998f624e818fbcb26364d584c8d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364198/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364198/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30783445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Weijing</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Sun, Pengfei</creatorcontrib><creatorcontrib>Zhou, Yanju</creatorcontrib><title>Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL-C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.</description><subject>Age</subject><subject>Angina pectoris</subject><subject>Atherosclerosis</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Coronary heart disease</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Enzymes</subject><subject>Females</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Homocysteine</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Low density lipoproteins</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Risk factors</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Triglycerides</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1v1DAQhiNERavSY6_IEhcuWfyZjC9I1VJYpEpc2rPlOHZxSeJgJ1X332PTpVCELXkszzOvx9ZbVecEbxhI-t4u44ZiApuWEPKiOiGtpDXBRLw87LEEclydpXSH8xANARCvqmOGW2Cci5PKXT7M0abkw4SCQzuzR3rqUTeE0KPBzz6v9t4OCfkJJRvXsWDb3Uc068XbaUm_eD3pYZ98Ksno03fktFlCTMiFWOjX1ZHTQ7Jnh3ha3Xy6vN7u6quvn79sL65qw1tYaiI7xpkGkwNnGFNtKHPaCSGczU2zrhVSgmsot0DAdaajDWt4L4Ab6Ak7rT486s5rN9re5AajHtQc_ajjXgXt1fPM5L-p23CvigqRkAXeHQRi-LHatKjRJ2OHQU82rElRApwwaERB3_6D3oU15o8olBRMNFjyP9StHqzykwv5XlNE1YVoQQCFts3U5j9Unr0dvQmTdT6fPyuoHwtMDClF657eSLAq3lDZG6p4QxVvZP7N3x_zRP92AvsJg-Gyew</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Liu, Weijing</creator><creator>Wang, Tao</creator><creator>Sun, Pengfei</creator><creator>Zhou, Yanju</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD</title><author>Liu, Weijing ; Wang, Tao ; Sun, Pengfei ; Zhou, Yanju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-19b343a8cb3443002ac23faf555fe3073b75998f624e818fbcb26364d584c8d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Angina pectoris</topic><topic>Atherosclerosis</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Cholesterol</topic><topic>Coronary heart disease</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Enzymes</topic><topic>Females</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart attack</topic><topic>Heart attacks</topic><topic>Heart diseases</topic><topic>Homocysteine</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Lipids</topic><topic>Lipoproteins</topic><topic>Low density lipoproteins</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Risk factors</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Triglycerides</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Weijing</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Sun, Pengfei</creatorcontrib><creatorcontrib>Zhou, Yanju</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Weijing</au><au>Wang, Tao</au><au>Sun, Pengfei</au><au>Zhou, Yanju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>17</volume><issue>3</issue><spage>1756</spage><epage>1760</epage><pages>1756-1760</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL-C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30783445</pmid><doi>10.3892/etm.2018.7111</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Angina pectoris Atherosclerosis Blood pressure Cardiovascular disease Cardiovascular diseases Care and treatment Cholesterol Coronary heart disease Development and progression Diabetes Enzymes Females Gene expression Genetic aspects Health aspects Heart Heart attack Heart attacks Heart diseases Homocysteine Hyperlipidemia Hypertension Lipids Lipoproteins Low density lipoproteins Medical research Metabolism Obesity Risk factors Statistical analysis Studies Triglycerides |
| title | Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD |
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