HDAC6 Restricts Influenza A Virus by Deacetylation of the RNA Polymerase PA Subunit

The life cycle of influenza A virus (IAV) is modulated by various cellular host factors. Although previous studies indicated that IAV infection is controlled by HDAC6, the deacetylase involved in the regulation of PA remained unknown. Here, we demonstrate that HDAC6 acts as a negative regulator of I...

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Veröffentlicht in:	Journal of virology 2019-02, Vol.93 (4)
Hauptverfasser:	Chen, Huan, Qian, Yingjuan, Chen, Xin, Ruan, Zhiyang, Ye, Yuetian, Chen, Hongjun, Babiuk, Lorne A, Jung, Yong-Sam, Dai, Jianjun
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Acetylation Animals Antiviral Agents - pharmacology Cell Line DNA-Directed RNA Polymerases - metabolism Dogs HEK293 Cells Histone Deacetylase 6 - metabolism Histone Deacetylase 6 - physiology Host-Pathogen Interactions - drug effects Humans Influenza A virus - metabolism Influenza A virus - pathogenicity Influenza, Human - genetics Influenza, Human - immunology Madin Darby Canine Kidney Cells RNA, Viral - metabolism Viral Proteins - metabolism Virus Replication - genetics Virus-Cell Interactions
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