P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X...

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Veröffentlicht in:	The Journal of experimental medicine 2019-02, Vol.216 (2), p.317-336
Hauptverfasser:	Faliti, Caterina E, Gualtierotti, Roberta, Rottoli, Elsa, Gerosa, Maria, Perruzza, Lisa, Romagnani, Andrea, Pellegrini, Giovanni, De Ponte Conti, Benedetta, Rossi, Riccardo L, Idzko, Marco, Mazza, Emilia M C, Bicciato, Silvio, Traggiai, Elisabetta, Meroni, Pier Luigi, Grassi, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - genetics Autoantibodies - immunology Disease Models, Animal Interferon-gamma - genetics Interferon-gamma - immunology Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Mice Mice, Knockout Pyroptosis - genetics Pyroptosis - immunology Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology
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