Extent of MHC Clustering Regulates Selectivity and Effectiveness of T Cell Responses

MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR engagement and TCR-mediated signaling has not been systematically studied. To evaluate the role of MHC clustering, we exploi...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-01, Vol.202 (2), p.591-597
Hauptverfasser:	Anikeeva, Nadia, Fischer, Nicholas O, Blanchette, Craig D, Sykulev, Yuri
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Binding Sites Biomimetics CD8-Positive T-Lymphocytes - immunology Histocompatibility Antigens Class I - immunology Humans Kinetics Lymphocyte Activation Peptides - chemistry Protein Binding Receptors, Antigen, T-Cell - immunology Signal Transduction
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