CHD1L contributes to cisplatin resistance by upregulating the ABCB1–NF-κB axis in human non-small-cell lung cancer

Chromodomain helicase/ATPase DNA binding protein 1-like gene ( CHD1L ) is a recently identified gene associated with malignant tumor progression and patient chemotherapy resistance in human hepatocellular carcinoma (HCC). Previously, we found an association between CHD1L overexpression and poor pati...

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Veröffentlicht in:	Cell death & disease 2019-02, Vol.10 (2), p.99-99, Article 99
Hauptverfasser:	Li, Yang, He, Li-Ru, Gao, Ying, Zhou, Ning-Ning, Liu, Yurong, Zhou, Xin-Ke, Liu, Ji-Fang, Guan, Xin-Yuan, Ma, Ning-Fang, Xie, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/31 13/51 13/89 13/95 38/79 45 631/67/1612/1350 692/53/2423 82/80 A549 Cells Adenosine triphosphatase Animals Antibodies Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis - genetics ATP Binding Cassette Transporter, Subfamily B - genetics ATP Binding Cassette Transporter, Subfamily B - metabolism Biochemistry Biomedical and Life Sciences c-Jun protein Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Cell Biology Cell Culture Cell survival Chemoresistance Chemotherapy Cisplatin Cisplatin - therapeutic use DNA helicase DNA Helicases - genetics DNA Helicases - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm - genetics Ectopic expression Female Gene Expression Regulation, Neoplastic - drug effects Hepatocellular carcinoma Humans Immunohistochemistry Immunology Life Sciences Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - mortality Male Mice Mice, Inbred BALB C Mice, Nude NF-kappa B - metabolism NF-κB protein Non-small cell lung carcinoma Patients Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Signal Transduction - drug effects Surgery Therapeutic applications Transcription factors Transcriptional Activation - drug effects Transplantation, Heterologous
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