Regional protein expression in human Alzheimer’s brain correlates with disease severity
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial s...
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| Veröffentlicht in: | Communications biology 2019-02, Vol.2 (1), p.43-43, Article 43 |
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| creator | Xu, Jingshu Patassini, Stefano Rustogi, Nitin Riba-Garcia, Isabel Hale, Benjamin D. Phillips, Alexander M Waldvogel, Henry Haines, Robert Bradbury, Phil Stevens, Adam Faull, Richard L. M. Dowsey, Andrew W. Cooper, Garth J. S. Unwin, Richard D. |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial scope of the study of AD and prioritise the study of human brains. Here we show that functionally distinct human brain regions display varying and region-specific changes in protein expression. These changes provide insights into the progression of disease, novel AD-related pathways, the presence of a gradient of protein expression change from less to more affected regions and a possibly protective protein expression profile in the cerebellum. This spatial proteomics analysis provides a framework which can underpin current research and open new avenues to enhance molecular understanding of AD pathophysiology, provide new targets for intervention and broaden the conceptual frameworks for future AD research.
Jingshu Xu et al. did a comprehensive post-mortem proteomics analysis across six brain regions obtained from Alzheimer’s disease patients and controls. With this spatial proteomics approach, they identified new disease-related pathways and a gradient of protein expression changes that correlates with the pathology of the affected regions. |
| doi_str_mv | 10.1038/s42003-018-0254-9 |
| format | Article |
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Jingshu Xu et al. did a comprehensive post-mortem proteomics analysis across six brain regions obtained from Alzheimer’s disease patients and controls. With this spatial proteomics approach, they identified new disease-related pathways and a gradient of protein expression changes that correlates with the pathology of the affected regions.</description><subject>631/1647/2067</subject><subject>631/378/1689/1283</subject><subject>631/45/475</subject><subject>631/45/612/1248</subject><subject>692/617/375/132/1283</subject><subject>82/16</subject><subject>82/58</subject><subject>82/80</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Autopsy</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Cerebellum</subject><subject>Cerebellum - metabolism</subject><subject>Cerebellum - pathology</subject><subject>Disease Progression</subject><subject>Entorhinal Cortex - metabolism</subject><subject>Entorhinal Cortex - pathology</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Gene Regulatory Networks</subject><subject>Gyrus Cinguli - metabolism</subject><subject>Gyrus Cinguli - pathology</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Cortex - metabolism</subject><subject>Motor Cortex - pathology</subject><subject>Nerve Tissue Proteins - classification</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurodegenerative diseases</subject><subject>Organ Specificity</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Signal Transduction</subject><subject>Somatosensory Cortex - metabolism</subject><subject>Somatosensory Cortex - pathology</subject><issn>2399-3642</issn><issn>2399-3642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9KHTEUxkNRqqgP0E0ZcONm2iQn8yebgki1glAQu-gq5GbO3BuZmdzmzGh15Wv4ej6JuVyrVnCVP9_vfMk5H2OfBP8iONRfSUnOIeeizrksVK4_sG0JWudQKrnxar_F9oguOedCa12C-si2gFdSi1pss9_nOPdhsF22jGFEP2T4dxmRKF1m6bSYejtkh93tAn2P8eHunrJZtElxIUbs7IiUXftxkTWe0BJmhFcY_XizyzZb2xHuPa077Nfx94ujH_nZz5PTo8Oz3KmKj3mhoVUApS1UpWwlUUjphFQlNE63ULlGNI113LbtrGoU19Y55ZTi5aodqGGHfVv7LqdZj43DYYy2M8voextvTLDe_K8MfmHm4cqUkCyKMhkcPBnE8GdCGk3vyWHX2QHDREamOVd1ARISuv8GvQxTTNNLFNS6rLnSIlFiTbkYiCK2z58R3KyyM-vsTMrOrLIzOtV8ft3Fc8W_pBIg1wAlaZhjfHn6fddHhpKmgA</recordid><startdate>20190204</startdate><enddate>20190204</enddate><creator>Xu, Jingshu</creator><creator>Patassini, Stefano</creator><creator>Rustogi, Nitin</creator><creator>Riba-Garcia, Isabel</creator><creator>Hale, Benjamin D.</creator><creator>Phillips, Alexander M</creator><creator>Waldvogel, Henry</creator><creator>Haines, Robert</creator><creator>Bradbury, Phil</creator><creator>Stevens, Adam</creator><creator>Faull, Richard L. 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M.</au><au>Dowsey, Andrew W.</au><au>Cooper, Garth J. S.</au><au>Unwin, Richard D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional protein expression in human Alzheimer’s brain correlates with disease severity</atitle><jtitle>Communications biology</jtitle><stitle>Commun Biol</stitle><addtitle>Commun Biol</addtitle><date>2019-02-04</date><risdate>2019</risdate><volume>2</volume><issue>1</issue><spage>43</spage><epage>43</epage><pages>43-43</pages><artnum>43</artnum><issn>2399-3642</issn><eissn>2399-3642</eissn><abstract>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that currently affects 36 million people worldwide with no effective treatment available. Development of AD follows a distinctive pattern in the brain and is poorly modelled in animals. Therefore, it is vital to widen the spatial scope of the study of AD and prioritise the study of human brains. Here we show that functionally distinct human brain regions display varying and region-specific changes in protein expression. These changes provide insights into the progression of disease, novel AD-related pathways, the presence of a gradient of protein expression change from less to more affected regions and a possibly protective protein expression profile in the cerebellum. This spatial proteomics analysis provides a framework which can underpin current research and open new avenues to enhance molecular understanding of AD pathophysiology, provide new targets for intervention and broaden the conceptual frameworks for future AD research.
Jingshu Xu et al. did a comprehensive post-mortem proteomics analysis across six brain regions obtained from Alzheimer’s disease patients and controls. With this spatial proteomics approach, they identified new disease-related pathways and a gradient of protein expression changes that correlates with the pathology of the affected regions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30729181</pmid><doi>10.1038/s42003-018-0254-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/1647/2067 631/378/1689/1283 631/45/475 631/45/612/1248 692/617/375/132/1283 82/16 82/58 82/80 Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Autopsy Biology Biomedical and Life Sciences Brain research Case-Control Studies Cerebellum Cerebellum - metabolism Cerebellum - pathology Disease Progression Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Gyrus Cinguli - metabolism Gyrus Cinguli - pathology Hippocampus - metabolism Hippocampus - pathology Humans Life Sciences Male Middle Aged Motor Cortex - metabolism Motor Cortex - pathology Nerve Tissue Proteins - classification Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegenerative diseases Organ Specificity Protein expression Proteins Proteomics Signal Transduction Somatosensory Cortex - metabolism Somatosensory Cortex - pathology |
| title | Regional protein expression in human Alzheimer’s brain correlates with disease severity |
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