The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics

Inherited genetic variations in pharmacogenetic loci are widely acknowledged as important determinants of phenotypic differences in drug response, and may be actionable in the clinic. However, recent studies suggest that a considerable number of novel rare variants in pharmacogenes likely contribute...

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Veröffentlicht in:	Cold Spring Harbor perspectives in medicine 2019-02, Vol.9 (2), p.a033027
Hauptverfasser:	Schwarz, Ute I, Gulilat, Markus, Kim, Richard B
Format:	Artikel
Sprache:	eng
Schlagworte:	Computational Biology Genetic Variation High-Throughput Nucleotide Sequencing - methods High-Throughput Screening Assays Humans Pharmacogenetics - methods Phenotype Sequence Analysis, DNA - methods
Online-Zugang:	Volltext
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