Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach
Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim of this study was to determinate the potential effect...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-9 |
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| creator | Sun, Wei Lian, Lejing Chen, Mengchun Huang, Cheng-ke Li, Wan-Shu Wang, Zhe Qian, Jianchang Cheng, Chen Dong, Yaoyao |
| description | Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim of this study was to determinate the potential effects of Corydalis decumbens on the five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6) by cocktail approach. To evaluate whether concurrent use of Corydalis decumbens interferes with the effect of several prescription drugs, saline (control group) or Corydalis decumbens (XTW group) were administrated via gavage for 7 successive days. A probe cocktail solution (phenacetin, omeprazole, metoprolol, tolbutamide, and midazolam) was given 24 h after the last dose of saline or Corydalis decumbens. A specific and sensitive UHPLC–MS/MS method was validated for the determination of five substrates and their metabolites in control group and XTW group. Our results indicated that Corydalis decumbens could have inductive effects of CYP2C19 and inhibit the activities of CYP1A2 and CYP3A4. However, Corydalis decumbens had no significant influence on CYP2C9 and CYP2D6. The herb-drug interaction should require more attention by careful monitoring and appropriate drug dosing adjustments to the concurrent use of western medications which were metabolized by CYP1A2, CYP2C19, and CYP3A4 in human—Corydalis decumbens, Cytochrome P450, Cocktail, Pharmacokinetics, herb–drug interactions. |
| doi_str_mv | 10.1155/2019/9614781 |
| format | Article |
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The aim of this study was to determinate the potential effects of Corydalis decumbens on the five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6) by cocktail approach. To evaluate whether concurrent use of Corydalis decumbens interferes with the effect of several prescription drugs, saline (control group) or Corydalis decumbens (XTW group) were administrated via gavage for 7 successive days. A probe cocktail solution (phenacetin, omeprazole, metoprolol, tolbutamide, and midazolam) was given 24 h after the last dose of saline or Corydalis decumbens. A specific and sensitive UHPLC–MS/MS method was validated for the determination of five substrates and their metabolites in control group and XTW group. Our results indicated that Corydalis decumbens could have inductive effects of CYP2C19 and inhibit the activities of CYP1A2 and CYP3A4. However, Corydalis decumbens had no significant influence on CYP2C9 and CYP2D6. The herb-drug interaction should require more attention by careful monitoring and appropriate drug dosing adjustments to the concurrent use of western medications which were metabolized by CYP1A2, CYP2C19, and CYP3A4 in human—Corydalis decumbens, Cytochrome P450, Cocktail, Pharmacokinetics, herb–drug interactions.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/9614781</identifier><identifier>PMID: 30800683</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acetanilide ; Arthritis ; Chinese medicine ; Corydalis decumbens ; CYP1A2 protein ; CYP2D6 protein ; Cytochrome ; Cytochrome P450 ; Cytochromes P450 ; Dosage ; Drug interaction ; Drug interactions ; Embolism ; Enzymatic activity ; Hemiplegia ; Herbal medicine ; Herbs ; Hypertension ; Metabolites ; Metoprolol ; Midazolam ; Omeprazole ; Paraplegia ; Pharmacokinetics ; Pharmacology ; Phenacetin ; Rheumatoid arthritis ; Sciatica ; Stroke ; Substrates ; Systematic review ; Tolbutamide ; Traditional Chinese medicine</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-9</ispartof><rights>Copyright © 2019 Chen Cheng et al.</rights><rights>Copyright © 2019 Chen Cheng et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Chen Cheng et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-35e0ec8afa775e96ee538d0a288bb5d47cc731de4117867f038fa85bcf6337373</citedby><cites>FETCH-LOGICAL-c471t-35e0ec8afa775e96ee538d0a288bb5d47cc731de4117867f038fa85bcf6337373</cites><orcidid>0000-0002-2431-0391 ; 0000-0002-8527-2616 ; 0000-0002-0453-7820 ; 0000-0002-1517-4869 ; 0000-0001-7582-3392</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360625/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360625/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30800683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aliev, Gjumrakch</contributor><contributor>Gjumrakch Aliev</contributor><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Lian, Lejing</creatorcontrib><creatorcontrib>Chen, Mengchun</creatorcontrib><creatorcontrib>Huang, Cheng-ke</creatorcontrib><creatorcontrib>Li, Wan-Shu</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Qian, Jianchang</creatorcontrib><creatorcontrib>Cheng, Chen</creatorcontrib><creatorcontrib>Dong, Yaoyao</creatorcontrib><title>Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim of this study was to determinate the potential effects of Corydalis decumbens on the five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6) by cocktail approach. To evaluate whether concurrent use of Corydalis decumbens interferes with the effect of several prescription drugs, saline (control group) or Corydalis decumbens (XTW group) were administrated via gavage for 7 successive days. A probe cocktail solution (phenacetin, omeprazole, metoprolol, tolbutamide, and midazolam) was given 24 h after the last dose of saline or Corydalis decumbens. A specific and sensitive UHPLC–MS/MS method was validated for the determination of five substrates and their metabolites in control group and XTW group. Our results indicated that Corydalis decumbens could have inductive effects of CYP2C19 and inhibit the activities of CYP1A2 and CYP3A4. However, Corydalis decumbens had no significant influence on CYP2C9 and CYP2D6. The herb-drug interaction should require more attention by careful monitoring and appropriate drug dosing adjustments to the concurrent use of western medications which were metabolized by CYP1A2, CYP2C19, and CYP3A4 in human—Corydalis decumbens, Cytochrome P450, Cocktail, Pharmacokinetics, herb–drug interactions.</description><subject>Acetanilide</subject><subject>Arthritis</subject><subject>Chinese medicine</subject><subject>Corydalis decumbens</subject><subject>CYP1A2 protein</subject><subject>CYP2D6 protein</subject><subject>Cytochrome</subject><subject>Cytochrome P450</subject><subject>Cytochromes P450</subject><subject>Dosage</subject><subject>Drug interaction</subject><subject>Drug interactions</subject><subject>Embolism</subject><subject>Enzymatic activity</subject><subject>Hemiplegia</subject><subject>Herbal medicine</subject><subject>Herbs</subject><subject>Hypertension</subject><subject>Metabolites</subject><subject>Metoprolol</subject><subject>Midazolam</subject><subject>Omeprazole</subject><subject>Paraplegia</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Phenacetin</subject><subject>Rheumatoid arthritis</subject><subject>Sciatica</subject><subject>Stroke</subject><subject>Substrates</subject><subject>Systematic review</subject><subject>Tolbutamide</subject><subject>Traditional Chinese 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of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach</title><author>Sun, Wei ; Lian, Lejing ; Chen, Mengchun ; Huang, Cheng-ke ; Li, Wan-Shu ; Wang, Zhe ; Qian, Jianchang ; Cheng, Chen ; Dong, Yaoyao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-35e0ec8afa775e96ee538d0a288bb5d47cc731de4117867f038fa85bcf6337373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetanilide</topic><topic>Arthritis</topic><topic>Chinese medicine</topic><topic>Corydalis decumbens</topic><topic>CYP1A2 protein</topic><topic>CYP2D6 protein</topic><topic>Cytochrome</topic><topic>Cytochrome P450</topic><topic>Cytochromes P450</topic><topic>Dosage</topic><topic>Drug interaction</topic><topic>Drug interactions</topic><topic>Embolism</topic><topic>Enzymatic activity</topic><topic>Hemiplegia</topic><topic>Herbal medicine</topic><topic>Herbs</topic><topic>Hypertension</topic><topic>Metabolites</topic><topic>Metoprolol</topic><topic>Midazolam</topic><topic>Omeprazole</topic><topic>Paraplegia</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Phenacetin</topic><topic>Rheumatoid arthritis</topic><topic>Sciatica</topic><topic>Stroke</topic><topic>Substrates</topic><topic>Systematic review</topic><topic>Tolbutamide</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Lian, Lejing</creatorcontrib><creatorcontrib>Chen, Mengchun</creatorcontrib><creatorcontrib>Huang, Cheng-ke</creatorcontrib><creatorcontrib>Li, Wan-Shu</creatorcontrib><creatorcontrib>Wang, Zhe</creatorcontrib><creatorcontrib>Qian, Jianchang</creatorcontrib><creatorcontrib>Cheng, Chen</creatorcontrib><creatorcontrib>Dong, Yaoyao</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Activities of CYP450 Enzymes in Rats with a Cocktail Approach</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Corydalis decumbens, a Traditional Chinese Medicine, has been widely used for the alternative and/or complementary therapy of hypertension, arrhythmias rheumatoid arthritis, sciatica, stroke, hemiplegia, paraplegia, and vascular embolism. The aim of this study was to determinate the potential effects of Corydalis decumbens on the five cytochrome P450 (CYP) enzyme activities (CYP1A2, CYP3A4, CYP2C9, CYP2C19, and CYP2D6) by cocktail approach. To evaluate whether concurrent use of Corydalis decumbens interferes with the effect of several prescription drugs, saline (control group) or Corydalis decumbens (XTW group) were administrated via gavage for 7 successive days. A probe cocktail solution (phenacetin, omeprazole, metoprolol, tolbutamide, and midazolam) was given 24 h after the last dose of saline or Corydalis decumbens. A specific and sensitive UHPLC–MS/MS method was validated for the determination of five substrates and their metabolites in control group and XTW group. Our results indicated that Corydalis decumbens could have inductive effects of CYP2C19 and inhibit the activities of CYP1A2 and CYP3A4. However, Corydalis decumbens had no significant influence on CYP2C9 and CYP2D6. The herb-drug interaction should require more attention by careful monitoring and appropriate drug dosing adjustments to the concurrent use of western medications which were metabolized by CYP1A2, CYP2C19, and CYP3A4 in human—Corydalis decumbens, Cytochrome P450, Cocktail, Pharmacokinetics, herb–drug interactions.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30800683</pmid><doi>10.1155/2019/9614781</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2431-0391</orcidid><orcidid>https://orcid.org/0000-0002-8527-2616</orcidid><orcidid>https://orcid.org/0000-0002-0453-7820</orcidid><orcidid>https://orcid.org/0000-0002-1517-4869</orcidid><orcidid>https://orcid.org/0000-0001-7582-3392</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetanilide Arthritis Chinese medicine Corydalis decumbens CYP1A2 protein CYP2D6 protein Cytochrome Cytochrome P450 Cytochromes P450 Dosage Drug interaction Drug interactions Embolism Enzymatic activity Hemiplegia Herbal medicine Herbs Hypertension Metabolites Metoprolol Midazolam Omeprazole Paraplegia Pharmacokinetics Pharmacology Phenacetin Rheumatoid arthritis Sciatica Stroke Substrates Systematic review Tolbutamide Traditional Chinese medicine |
| title | Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach |
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