Association of mGluR-Dependent LTD of Excitatory Synapses with Endocannabinoid-Dependent LTD of Inhibitory Synapses Leads to EPSP to Spike Potentiation in CA1 Pyramidal Neurons

The input-output relationships in neural circuits are determined not only by synaptic efficacy but also by neuronal excitability. Activity-dependent alterations of synaptic efficacy have been extensively investigated, but relatively less is known about how the neuronal output is modulated when synap...

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Veröffentlicht in:	The Journal of neuroscience 2019-01, Vol.39 (2), p.224-237
Hauptverfasser:	Kim, Hye-Hyun, Park, Joo Min, Lee, Suk-Ho, Ho, Won-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - physiology Animals CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - physiology Cannabinoid Receptor Antagonists - pharmacology Cannabinoid receptors Current injection Effectiveness Endocannabinoids - physiology Excitability Excitatory postsynaptic potentials Excitatory Postsynaptic Potentials - physiology Female GABA Agonists - pharmacology GABA Antagonists - pharmacology Glutamic acid receptors (metabotropic) Hyperpolarization Inhibitory postsynaptic potentials Long-Term Synaptic Depression - physiology Male Neural networks Neurons Piperidines - pharmacology Potentiation Pyramidal cells Pyramidal Cells - physiology Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, Metabotropic Glutamate - metabolism Reduction Signaling Stimulation Synapses Synapses - physiology Synaptic strength Threshold voltage γ-Aminobutyric acid receptors
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