Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)
IntroductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable...
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| creator | Martin, Kathryn R Bachmair, Eva-Maria Aucott, Lorna Dures, Emma Emsley, Richard Gray, Stuart R Hewlett, Sarah Kumar, Vinod Lovell, Karina Macfarlane, Gary J MacLennan, Graeme McNamee, Paul Norrie, John Paul, Lorna Ralston, Stuart Siebert, Stefan Wearden, Alison White, Peter D Basu, Neil |
| description | IntroductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue.Methods and analysisLIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls.Ethics approval and disseminationEthical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants.Trial registration number NCT03248518; Pre-results. |
| doi_str_mv | 10.1136/bmjopen-2018-026793 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6359876</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2173532318</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-52816aa818ff1e5b7d719fb3174d311773691cb535aeb6e3afd78696d9514f483</originalsourceid><addsrcrecordid>eNqNksGL1DAUxqso7rIueBck4GU9dG2aJm0vgiyuLgzoYT2HtH3pZEiTMUlH57_3dWZcVk-WQh_J733fS_pl2WtaXFPKxPtu2vgtuLwsaJMXpahb9jQ7L4uqykXB-bNH9Vl2GeOmwKfiLefli-yMFXXBy6o6f_LqW_DJ994S7QNRZJptMj24FIAE5QY_mQgD6T2ueGux3KqgsLD5GPy8JSkYZUnyiEy4BSStgYDW0CezAwcxEq9JgMknsHsygMXlcJAcnVmYvIO12hk_oy5BSzIGNSAAvyD06E6MSxBQKxnvIvlp0prMcUa4X_yU9Q6WASx6gTv4GxylT4uxVsmM86KBr7ZqmlTyYU_CGmYsTU8GtFARIrla3d3ev3uZPdfKRrg8fS-y77ef7m--5Kuvn-9uPq7yrqrLlPOyoUKphjZaU-BdPdS01R2jdTUwSuuaiZb2HWdcQSeAKT3UjWjF0HJa6aphF9mHo-527iYYDleurNwGM6mwl14Z-feOM2s5-p0UjLdNLVDg6iQQ_I8ZYpL4q3qwVjnwc5QlrdtKcCZKRN_-g27wth0eb6EYZyWjy0TsSPXBxxhAPwxDC7mETp5CJ5fQyWPosOvN43M89PyJGALXRwC7_0vxNy-I618</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2173532318</pqid></control><display><type>article</type><title>Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)</title><source>BMJ Open Access Journals</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Martin, Kathryn R ; Bachmair, Eva-Maria ; Aucott, Lorna ; Dures, Emma ; Emsley, Richard ; Gray, Stuart R ; Hewlett, Sarah ; Kumar, Vinod ; Lovell, Karina ; Macfarlane, Gary J ; MacLennan, Graeme ; McNamee, Paul ; Norrie, John ; Paul, Lorna ; Ralston, Stuart ; Siebert, Stefan ; Wearden, Alison ; White, Peter D ; Basu, Neil</creator><creatorcontrib>Martin, Kathryn R ; Bachmair, Eva-Maria ; Aucott, Lorna ; Dures, Emma ; Emsley, Richard ; Gray, Stuart R ; Hewlett, Sarah ; Kumar, Vinod ; Lovell, Karina ; Macfarlane, Gary J ; MacLennan, Graeme ; McNamee, Paul ; Norrie, John ; Paul, Lorna ; Ralston, Stuart ; Siebert, Stefan ; Wearden, Alison ; White, Peter D ; Basu, Neil</creatorcontrib><description>IntroductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue.Methods and analysisLIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls.Ethics approval and disseminationEthical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants.Trial registration number NCT03248518; Pre-results.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2018-026793</identifier><identifier>PMID: 30705244</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Chronic illnesses ; Cognitive Behavioral Therapy - methods ; Cost-Benefit Analysis ; Employment ; Evidence-based medicine ; Exercise ; Exercise Therapy - methods ; Fatigue ; Fatigue - therapy ; Fibromyalgia ; Humans ; Lupus ; Methods ; Multicenter Studies as Topic ; Multiple sclerosis ; Pain ; Patient satisfaction ; Qualitative research ; Quality of Life ; Questionnaires ; Randomized Controlled Trials as Topic ; Rheumatic diseases ; Rheumatic Fever - physiopathology ; Rheumatic Fever - therapy ; Rheumatoid arthritis ; Rheumatology ; Severity of Illness Index</subject><ispartof>BMJ open, 2019-01, Vol.9 (1), p.e026793-e026793</ispartof><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-52816aa818ff1e5b7d719fb3174d311773691cb535aeb6e3afd78696d9514f483</citedby><cites>FETCH-LOGICAL-b472t-52816aa818ff1e5b7d719fb3174d311773691cb535aeb6e3afd78696d9514f483</cites><orcidid>0000-0001-7851-2039</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/9/1/e026793.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/9/1/e026793.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27549,27550,27924,27925,53791,53793,77601,77632</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30705244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, Kathryn R</creatorcontrib><creatorcontrib>Bachmair, Eva-Maria</creatorcontrib><creatorcontrib>Aucott, Lorna</creatorcontrib><creatorcontrib>Dures, Emma</creatorcontrib><creatorcontrib>Emsley, Richard</creatorcontrib><creatorcontrib>Gray, Stuart R</creatorcontrib><creatorcontrib>Hewlett, Sarah</creatorcontrib><creatorcontrib>Kumar, Vinod</creatorcontrib><creatorcontrib>Lovell, Karina</creatorcontrib><creatorcontrib>Macfarlane, Gary J</creatorcontrib><creatorcontrib>MacLennan, Graeme</creatorcontrib><creatorcontrib>McNamee, Paul</creatorcontrib><creatorcontrib>Norrie, John</creatorcontrib><creatorcontrib>Paul, Lorna</creatorcontrib><creatorcontrib>Ralston, Stuart</creatorcontrib><creatorcontrib>Siebert, Stefan</creatorcontrib><creatorcontrib>Wearden, Alison</creatorcontrib><creatorcontrib>White, Peter D</creatorcontrib><creatorcontrib>Basu, Neil</creatorcontrib><title>Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>IntroductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue.Methods and analysisLIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls.Ethics approval and disseminationEthical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants.Trial registration number NCT03248518; Pre-results.</description><subject>Chronic illnesses</subject><subject>Cognitive Behavioral Therapy - methods</subject><subject>Cost-Benefit Analysis</subject><subject>Employment</subject><subject>Evidence-based medicine</subject><subject>Exercise</subject><subject>Exercise Therapy - methods</subject><subject>Fatigue</subject><subject>Fatigue - therapy</subject><subject>Fibromyalgia</subject><subject>Humans</subject><subject>Lupus</subject><subject>Methods</subject><subject>Multicenter Studies as Topic</subject><subject>Multiple sclerosis</subject><subject>Pain</subject><subject>Patient satisfaction</subject><subject>Qualitative research</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rheumatic diseases</subject><subject>Rheumatic Fever - physiopathology</subject><subject>Rheumatic Fever - therapy</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Severity of Illness Index</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksGL1DAUxqso7rIueBck4GU9dG2aJm0vgiyuLgzoYT2HtH3pZEiTMUlH57_3dWZcVk-WQh_J733fS_pl2WtaXFPKxPtu2vgtuLwsaJMXpahb9jQ7L4uqykXB-bNH9Vl2GeOmwKfiLefli-yMFXXBy6o6f_LqW_DJ994S7QNRZJptMj24FIAE5QY_mQgD6T2ueGux3KqgsLD5GPy8JSkYZUnyiEy4BSStgYDW0CezAwcxEq9JgMknsHsygMXlcJAcnVmYvIO12hk_oy5BSzIGNSAAvyD06E6MSxBQKxnvIvlp0prMcUa4X_yU9Q6WASx6gTv4GxylT4uxVsmM86KBr7ZqmlTyYU_CGmYsTU8GtFARIrla3d3ev3uZPdfKRrg8fS-y77ef7m--5Kuvn-9uPq7yrqrLlPOyoUKphjZaU-BdPdS01R2jdTUwSuuaiZb2HWdcQSeAKT3UjWjF0HJa6aphF9mHo-527iYYDleurNwGM6mwl14Z-feOM2s5-p0UjLdNLVDg6iQQ_I8ZYpL4q3qwVjnwc5QlrdtKcCZKRN_-g27wth0eb6EYZyWjy0TsSPXBxxhAPwxDC7mETp5CJ5fQyWPosOvN43M89PyJGALXRwC7_0vxNy-I618</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Martin, Kathryn R</creator><creator>Bachmair, Eva-Maria</creator><creator>Aucott, Lorna</creator><creator>Dures, Emma</creator><creator>Emsley, Richard</creator><creator>Gray, Stuart R</creator><creator>Hewlett, Sarah</creator><creator>Kumar, Vinod</creator><creator>Lovell, Karina</creator><creator>Macfarlane, Gary J</creator><creator>MacLennan, Graeme</creator><creator>McNamee, Paul</creator><creator>Norrie, John</creator><creator>Paul, Lorna</creator><creator>Ralston, Stuart</creator><creator>Siebert, Stefan</creator><creator>Wearden, Alison</creator><creator>White, Peter D</creator><creator>Basu, Neil</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7851-2039</orcidid></search><sort><creationdate>20190101</creationdate><title>Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)</title><author>Martin, Kathryn R ; Bachmair, Eva-Maria ; Aucott, Lorna ; Dures, Emma ; Emsley, Richard ; Gray, Stuart R ; Hewlett, Sarah ; Kumar, Vinod ; Lovell, Karina ; Macfarlane, Gary J ; MacLennan, Graeme ; McNamee, Paul ; Norrie, John ; Paul, Lorna ; Ralston, Stuart ; Siebert, Stefan ; Wearden, Alison ; White, Peter D ; Basu, Neil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-52816aa818ff1e5b7d719fb3174d311773691cb535aeb6e3afd78696d9514f483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chronic illnesses</topic><topic>Cognitive Behavioral Therapy - methods</topic><topic>Cost-Benefit Analysis</topic><topic>Employment</topic><topic>Evidence-based medicine</topic><topic>Exercise</topic><topic>Exercise Therapy - methods</topic><topic>Fatigue</topic><topic>Fatigue - therapy</topic><topic>Fibromyalgia</topic><topic>Humans</topic><topic>Lupus</topic><topic>Methods</topic><topic>Multicenter Studies as Topic</topic><topic>Multiple sclerosis</topic><topic>Pain</topic><topic>Patient satisfaction</topic><topic>Qualitative research</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Rheumatic diseases</topic><topic>Rheumatic Fever - physiopathology</topic><topic>Rheumatic Fever - therapy</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, Kathryn R</creatorcontrib><creatorcontrib>Bachmair, Eva-Maria</creatorcontrib><creatorcontrib>Aucott, Lorna</creatorcontrib><creatorcontrib>Dures, Emma</creatorcontrib><creatorcontrib>Emsley, Richard</creatorcontrib><creatorcontrib>Gray, Stuart R</creatorcontrib><creatorcontrib>Hewlett, Sarah</creatorcontrib><creatorcontrib>Kumar, Vinod</creatorcontrib><creatorcontrib>Lovell, Karina</creatorcontrib><creatorcontrib>Macfarlane, Gary J</creatorcontrib><creatorcontrib>MacLennan, Graeme</creatorcontrib><creatorcontrib>McNamee, Paul</creatorcontrib><creatorcontrib>Norrie, John</creatorcontrib><creatorcontrib>Paul, Lorna</creatorcontrib><creatorcontrib>Ralston, Stuart</creatorcontrib><creatorcontrib>Siebert, Stefan</creatorcontrib><creatorcontrib>Wearden, Alison</creatorcontrib><creatorcontrib>White, Peter D</creatorcontrib><creatorcontrib>Basu, Neil</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, Kathryn R</au><au>Bachmair, Eva-Maria</au><au>Aucott, Lorna</au><au>Dures, Emma</au><au>Emsley, Richard</au><au>Gray, Stuart R</au><au>Hewlett, Sarah</au><au>Kumar, Vinod</au><au>Lovell, Karina</au><au>Macfarlane, Gary J</au><au>MacLennan, Graeme</au><au>McNamee, Paul</au><au>Norrie, John</au><au>Paul, Lorna</au><au>Ralston, Stuart</au><au>Siebert, Stefan</au><au>Wearden, Alison</au><au>White, Peter D</au><au>Basu, Neil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>e026793</spage><epage>e026793</epage><pages>e026793-e026793</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>IntroductionFatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue.Methods and analysisLIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls.Ethics approval and disseminationEthical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants.Trial registration number NCT03248518; Pre-results.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30705244</pmid><doi>10.1136/bmjopen-2018-026793</doi><orcidid>https://orcid.org/0000-0001-7851-2039</orcidid><oa>free_for_read</oa></addata></record> |
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| source | BMJ Open Access Journals; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Chronic illnesses Cognitive Behavioral Therapy - methods Cost-Benefit Analysis Employment Evidence-based medicine Exercise Exercise Therapy - methods Fatigue Fatigue - therapy Fibromyalgia Humans Lupus Methods Multicenter Studies as Topic Multiple sclerosis Pain Patient satisfaction Qualitative research Quality of Life Questionnaires Randomized Controlled Trials as Topic Rheumatic diseases Rheumatic Fever - physiopathology Rheumatic Fever - therapy Rheumatoid arthritis Rheumatology Severity of Illness Index |
| title | Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT) |
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