Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

Current (high throughput omics-based) data support the model that human (malignant) germ cell tumors are not initiated by somatic mutations, but, instead through a defined locked epigenetic status, representative of their cell of origin. This elegantly explains the role of both genetic susceptibilit...

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Veröffentlicht in:	International journal of molecular sciences 2019-01, Vol.20 (2), p.258
Hauptverfasser:	Lobo, João, Gillis, Ad J M, Jerónimo, Carmen, Henrique, Rui, Looijenga, Leendert H J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Atrophy Biomarkers, Tumor BRCA1 protein Cardiovascular diseases Cell cycle Cell Transformation, Neoplastic - genetics Cisplatin Cryptorchidism Cytotoxic agents Cytotoxicity DNA damage DNA repair Environment Epidemiology Epigenesis, Genetic Epigenetics Fertility Gene-Environment Interaction Genetic Predisposition to Disease Health risk assessment Hernia Humans Incidence Life span Neoplasms, Germ Cell and Embryonal - epidemiology Neoplasms, Germ Cell and Embryonal - etiology Neoplasms, Germ Cell and Embryonal - pathology Nucleotides Polygenic inheritance Quality of life Radiation therapy Review Risk analysis Risk factors Sex determination Single-nucleotide polymorphism Spermatogenesis Testes Testicular cancer Tumors
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