Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

In a previous paper, we reported that triptolide (TP), a commonly used immunomodulator, could attenuate cardiac hypertrophy. This present study aimed to further explore the inhibition of cardiac fibrosis by TP and the possible mechanism from the perspective of the NOD-like receptor protein 3 (NLRP3)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2019-01, Vol.20 (2), p.360
Hauptverfasser:	Pan, Xi-Chun, Liu, Ya, Cen, Yan-Yan, Xiong, Ya-Lan, Li, Jing-Mei, Ding, Yuan-Yuan, Tong, Yang-Fei, Liu, Tao, Chen, Xiao-Hong, Zhang, Hai-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II Animals Apoptosis Cardiomyopathy Collagen Collagen - metabolism Diabetes mellitus Diterpenes - pharmacology Down-Regulation - drug effects Enzyme Activation - drug effects Epoxy Compounds - pharmacology Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Heart Heart Ventricles - pathology Inflammasomes Inflammasomes - metabolism Influence Isoproterenol Kinases Male MAP Kinase Signaling System - drug effects Mice, Inbred C57BL Morphology Myocardium - metabolism Myocardium - pathology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pathogens Phenanthrenes - pharmacology Proteins Smad protein Smad Proteins - metabolism Smad2 protein Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Triptolide
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!