p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions

The hYSK1, a serine/threonine kinase (STK)-25, has been implicated in a variety of cellular functions including cell migration and polarity. We have recently reported that hYSK1 down-regulated the expression and functions of p16INK4a, a cell cycle regulatory protein, thereby enhancing migration and...

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Veröffentlicht in:	International journal of molecular sciences 2019-01, Vol.20 (2), p.310
Hauptverfasser:	Lee, Mee-Hyun, Kundu, Joydeb Kumar, Choi, Bu Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Cancer Cell activation Cell adhesion & migration Cell cycle Cell growth Cell proliferation Cyclin-dependent kinase 4 Cyclin-dependent kinase inhibitor p21 Cyclin-dependent kinases DNA-directed RNA polymerase E2F protein Endometrial cancer Endometrium Epigenetics Gelatinase A Genes Genomes Glioma Hypoxia INK4a protein Kinases Localization Mutation p16 Protein Phosphorylation Proteins RNA polymerase RNA polymerase II Transcription activation Transcription factors Tumor cells Tumors
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